Although significant advances in malaria control have been made in the past few decades, resistance to our current antimalarial drug repertoire threatens control efforts.
Membrane transport proteins, also known as transporters, are crucial for the maintenance of cell physiology by facilitating the movement of ions, nutrients, metabolites, and waste across cell membranes.
F1Fo ATP synthase generates the majority of cellular energy by interconverting phosphate transfer energy and proton motive force via a rotary catalytic mechanism. Using cryo electron microscopy we have provided molecular snapshots of this complex enzyme in multiple states.
The Acinetobacter genus includes at least 70 named species that occupy environments which differ broadly in nutrient composition, water availability, temperature and other abiotic characteristics.
Malaria remains the deadliest parasitic disease in the world despite years of sustained effort, new drug development, and a greater understanding of the causative parasite, Plasmodium, and its interactions with its host.
Developing novel synthetic microbes for the sustainable production of biochemical, biofuels and bioplastics is critical for the emergence of a new global bioeconomy.