Many proteins migrate from cytoplasm to nucleus through their recognition by specialist receptors known as importins (IMPs).

Bacteriophages, with their intricate and highly specialized structures, represent some of the most fascinating architectures in the biological world. These viral entities serve as a sustainable and eco-friendly alternative to chemical treatments in agriculture and as biocontrol agents against bacterial pathogens.

Natural products have long been celebrated as a treasure trove of therapeutic agents, serving as the foundation for many life-saving drugs. This general talk outlines possible approaches to the discovery and development of small molecule therapeutics for the treatment of inflammation and infectious diseases.

This presentation highlights high-resolution cryo-EM structures of C. albicans Cdr1 in various substrate-bound states, with and without nucleotides, resolved at 3.45–3.74 Å.

Making key insights into antimalarial resistance mechanisms and delineate the utility of cutting-edge computational approaches that will go on to inform future drug design strategies and efforts.

Over 50 years ago, the active principle 青蒿素 qīng hāo sū or artemisinin was isolated in pure crystal-line form from the leaves of the Chinese traditional herb 青蒿 qīng hāo - Artemisia annua - by Chinese groups working under the remarkable Project 523 during the latter stages of the Chinese Cultural Revolution.