Erythrocyte host modifications in Plasmodium falciparum

Description

Malaria is a deadly disease, caused by parasite Plasmodium falciparum, that affects a large percentage of the world’s population. Symptoms of severe malaria arise from the asexual stage of the parasite life cycle, which occurs in human red blood cells. The parasite exports a large number of proteins to the host membrane where the proteins interact with the cytoskeletal network or express on the surface where it binds to human endothelial receptors. This leads to decreased deformability and sequestration of infected cells in microvasculature often leading to organ failure and death. This project worked on characterising the function of a novel export protein, PFB0115w, thought to be involved in the presentation of virulent surface antigens at the host membrane and on developing a flow-based method to quantify deformability of infected cells.

Date & time

1–2.30pm 14 February 2019

Location

Eucalyptus Seminar Room (S2.05), Level 2,
RN Robertson Building (46), ANU

Speakers

Melanie Ridgway and Meenu Pratap - Maier Group PhD candidates

Contacts

 Giel van Dooren
 61 (0)2 6125 0665

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