Biomedical Science and Biochemistry Seminar Series
Seminars from the RSB Division of Biomedical Science and Biochemistry.
1pm 30 March 2023
Alastair Stewart, Victor Chang Cardiac Research Institute
F1Fo ATP synthase generates the majority of cellular energy by interconverting phosphate transfer energy and proton motive force via a rotary catalytic mechanism. Using cryo electron microscopy we have provided molecular snapshots of this complex enzyme in multiple states.
BSB Seminar: A decade of research into Acinetobacter efflux pumps »
The Acinetobacter genus includes at least 70 named species that occupy environments which differ broadly in nutrient composition, water availability, temperature and other abiotic characteristics.
BSB PhD Exit Seminar: Plasmodium falciparum lipid metabolism as a target for malaria intervention strategies »
Malaria remains the deadliest parasitic disease in the world despite years of sustained effort, new drug development, and a greater understanding of the causative parasite, Plasmodium, and its interactions with its host.
BSB MPhil Exit Seminar: Understanding patterns of collateral sensitivity in the malaria parasite »
Malaria kills around 400,000 people each year and the prevention and treatment of this disease is highly reliant on chemotherapy.
BSB Seminar: The ARC Centre of Excellence in Synthetic Biology - Inspired by Nature, Designed by Science »
Developing novel synthetic microbes for the sustainable production of biochemical, biofuels and bioplastics is critical for the emergence of a new global bioeconomy.
BSB Seminar: Silently Shaping Structure – Probing for an association between codon usage and very local protein structure »
One of the most fundamental assumptions in biology is that the amino acid sequence defines protein structure and that this sequence carries no memory of the specific mRNA codon sequence from which it was translated.
BSB Seminar: Molecular mechanisms underscoring mitochondrial disease »
Mitochondrial diseases (MDs) are the largest and most common group of inherited metabolic disorders. They comprise over 350 monogenic diseases and affect at least one child born each week in Australia.
BSB Seminar: The battle for nutrients at the host-pathogen interface: They are what you eat »
Nutritional deficiencies are a leading cause of human susceptibility to infectious diseases and antibiotic treatment failure. Specifically, our intake of dietary lipids has changed dramatically, yet microbe-lipid interactions during infection are poorly understood.
BSB Seminar: The structure of a tripartite ATP-independent periplasmic (TRAP) transporter provides the molecular basis for function »
Bacterial infections remain a global public health challenge and there is a critical need for the identification and molecular understanding of new targets for antimicrobial design.
BSB Seminar: Metabolomics and proteomics approaches to enhance drug discovery for malaria »
Current treatments for malaria are threatened by drug resistance, and new antimalarials are urgently required to ensure the continued ability to treat malaria infections into the future.
BSB PhD Exit Seminar: Expression studies and pharmacology of neutral amino acid transporter B0AT1 (SLC6A19) - A potential target to treat metabolic diseases »
B0AT1 (Slc6a19) is a sodium-dependent neutral amino acid transporter catalyzing the secondary active transport of neutral amino acids across the brush border membrane of the kidney and intestine.
BSB PhD Exit Seminar: Characterising aspects of the CoA biosynthesis pathway in P. falciparum and T. gondii »
Malaria is an ancient disease leading to the death of more than half a million people every year.
BSB Seminar: Molecular structure of the intact bacterial flagellar basal body »
Bacterial flagella self-assemble a strong, multi-component drive shaft that couples rotation in the inner membrane to the microns-long flagellar filament that powers bacterial swimming in viscous fluids.
BSB PhD Exit Seminar: Amodiaquine resistance in the malaria parasite – revealing the How »
The antimalarial drug amodiaquine has been around for nearly 60 years during which time it has been deployed as a monotherapy, then removed from recommendations due to toxicity fears, re-instated, and is now deployed in artemisinin-based combinations therapies to combat malaria.
BSB PhD Exit Seminar: Elucidating and exploiting the mitochondrial electron transport chain of T. gondii parasites »
As you read this abstract, your lungs are (I hope!) bringing live-sustaining oxygen into your body. Oxygen is required by our cells for one key purpose – to act as the final electron acceptor in the mitochondrial electron transport chain (ETC).
BSB PhD Exit Seminar: Study of the functional roles of hypothetical proteins in the virulence of Shigella flexneri serotype 1c »
Shigella flexneri is an entero-pathogen that is considered a significant public health risk, causing shigellosis or bacillary dysentery, and accounts for the highest percentage of diarrheal deaths annually.