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Infection and immunity

RSB studies immune responses to pathogens like Shigella and poxviruses, exploring immune system development and its role in fighting infections and cancer. Research supports vaccine creation and cancer therapies.

About

Organisms defend themselves against infections through innate and adaptive immune responses. In the Research School of Biology we investigate important pathogens (Shigella, poxviruses and herpesviruses) and how they are recognised by the immune system. We investigate how cells of the immune system develop and how the immune system can be used to fight infectious agents and cancer cells. These approaches are used to generate new vaccines and to develop cancer therapies.

Groups

An image showing a chemical structure on a blue background next to a colorful illustration of a dendritic cell.

The Altin group on tumour immunology and liposome targeting.

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Fahrer group

We are working on a very simple and inexpensive cancer immunotherapy treatment, and a bioinformatics study looking for novel proteins in different genomes.

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A 3D rendering of a tangled purple protein chain with two green molecules embedded within it.

We aim to identify new potential targets for antibacterial agents, using structural biology, biochemistry and bacteriology methods.

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Five people smiling and sitting at an outdoor bench in a parklike setting with trees and a building in the background.

We study membrane transport processes in the Plasmodium parasites that cause malaria.

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Maier group

The Maier Group focusses on the identification of molecules involved in malaria pathogenesis and transmission.

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Logo for ANU Bee Lab featuring a stylized bee above the letters "ANU" with "BEE LAB" in a yellow rectangle.

Our research actually spans may study systems and research questions. But the evolution of honey bee parasites and diseases and is a major focus.

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Illustration of a green plant with multiple leaves, some of which have yellow spots, on a white background.

Rathjen group focuses on all aspects of plant immunity, characterising the fascinating interplay between host and pathogen.

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Microscopic view of cells with prominent nuclei, showing detailed internal structures.

We investigate the molecular mechanism of the O-antigen modification in S. flexneri by studying the structure proteins responsible for these changes.

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Illustration showing various colored molecular structures superimposed on a plant image with yellow nodules on its stems.

We aim to understand the molecular basis of the interactions between plant hosts and the microorganisms, particularly fungi, that colonise them.

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Projects

Chytrid fungal infections are responsible for the extinction of over 90 frog species. In 1998, Australian researchers identified the chytrid fungus Batrachochytrium dendrobatidis (Bd) as the causative agent for chytridiomycosis, a deadly skin disease affecting frog populations globally.

Student intake

Open for Honours, Master, PhD students

People

Using yeast surface display synthetic biology for a nanobody production platform.

Student intake

Open for Bachelor, Honours, Master, PhD students

People

In recent years, C. elegans (a soil-dwelling nematode) has become an attractive animal model to study host-pathogen interactions. My group is investigating the feasibility of this model to study Shigella pathogenesis at the molecular level.

Student intake

Open for Master, PhD students

People

The nessy mouse has a mutation which prevents normal development of T cells. The mutation affects a protein (kleisin beta) involved in chromosome structure. This is an unexpected finding which links two exciting fields of research.

Dr Fahrer has published a hypothesis paper suggesting a new method of treating tumours, using an old and inexpensive preparation, that could be of considerable benefit to patients and their cancer management.

Student intake

Open for Honours, PhD students

People

Autotransporters are a large family of virulence proteins produced by Gram-negative bacterial pathogens responsible for infectious diseases such as diarrhoea, whooping cough, cholera, chlamydia, and bacterial meningitis.

Student intake

Open for Bachelor, Honours students

People

News

A low-cost, non-toxic cancer treatment has been developed by researchers at The Australian National University (ANU). The treatment uses dead bacteria to help kick-start the immune system and shrink cancer.

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Wheat

Some clever detective work by an international team of scientists has uncovered how a deadly fungus - a stem rust called Ug99 - came about through some unusual breeding habits. The discovery will help protect wheat crops around the world from devastating fungal diseases.

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Aude Fahrer's work aims to activate the immune cells responsible for attacking cancer, in a simple, low cost way.

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Researchers have a new understanding of the genetic makeup of a fungus that causes the disease Wheat Stripe Rust, one of the most destructive wheat diseases globally costing $1 billion annually.

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One of the malaria parasite's best weapons against drug treatments turns out to be an Achilles' heel, which could be exploited to cure the deadly disease.

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