Tham Group - Understanding chytrid infection biology
We are interested in understanding the biology of chytrid fungus and how it infects frogs with the aim of developing novel interventions.
Research themes
About
Chytrid fungus is one of the most lethal wildlife pathogens, contributing to the extinction of over 90 frog species.
Our research aims to understand how chytrid fungus infects frogs by combining structural biology and genetic modification approaches. We use artificial intelligence-driven pipelines to identify key fungal proteins involved in infection and to design nanobodies that target them. Using nanobodies and genetic modification tools, we will examine which virulence proteins are essential for frog infection, with the goal of developing targeted interventions.
Grants
Outram M, Hill E, Solomon P & Tham WH. Deciphering the role of cell death effectors in frog chytrid fungi. Herman Slade Foundation.
Outram M. Artificial intelligence-driven discovery of frog chytrid virulence factors to combat disease. Thomas Davies Research Grant for Marine, Soil and Plant Biology (AAAS).
Projects
Members
Group Leader
Academic Lead
ANU Nanobody Facility (BRF)
