In recent years, C. elegans (a soil-dwelling nematode) has become an attractive animal model to study host-pathogen interactions. My group is investigating the feasibility of this model to study Shigella pathogenesis at the molecular level. We have identified a large number of proteins/genes that are differentially expressed in C. elegans when exposed to Shigella using both proteomic and transcriptomic approaches. We are examining what specific pathways are activated in C. elegans in response to Shigella infection and how they contribute to the Shigella-induced pathogenesis in the worm.