Using yeast surface display synthetic biology for a nanobody production platform.

Yeast fermentation is a multi-billion dollar global industry, at the basis of many new Synthetic Biology companies. A key aspect of this technology is being able to efficiently excrete high value protein products from the yeast cells which significantly simplifies downstream purification.

The best treatment for Malaria is currently via the combination of the drugs Artemisin and Piperaquine, but emerging resistance to both of these front-line antimalarial drugs means there is an urgent need for new treatment options and a better understanding of resistance mechanisms.

The cells of our organs must form tight barriers with each other in order to differentiate themselves and perform their function. These cellular junctions and attachments display exquisite mechanical and chemical sensitivity that if perturbed, often leads to disease states within the body.

Understanding how Resolvin signalling is mediated by this mechanism has therapeutic implications for all diseases where a state of chronic inflammation is involved, from arthritis to depression.

We use modern tools like golden gate cloning and CRISPR to design and build living biosensors.