Engineering the secretory pathways of yeast

Yeast fermentation is a multi-billion dollar global industry, at the basis of many new Synthetic Biology companies. A key aspect of this technology is being able to efficiently excrete high value protein products from the yeast cells which significantly simplifies downstream purification.

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Illustration of a molecular diagram showing the processing of insulin with components like ribosome, translocon, and cleavage sites for signal peptide and insulin chains.

Yeast fermentation is a multi-billion dollar global industry, at the basis of many new Synthetic Biology companies. A key aspect of this technology is being able to efficiently excrete high value protein products from the yeast cells which significantly simplifies downstream purification.

 

This project seeks to engineer a universal secretion system for Saccharomyces cerevisiae, which can be applied to any protein targeted for secretion with high efficiency.

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