Natural products have long been celebrated as a treasure trove of therapeutic agents, serving as the foundation for many life-saving drugs. This general talk outlines possible approaches to the discovery and development of small molecule therapeutics for the treatment of inflammation and infectious diseases.

Phylogenetic distance is a key measure used to develop host test lists that will delimit the fundamental and realised host range of candidate biocontrol agents.

Our group is broadly interested in understanding how metazoan cells fold complex proteins, and how the need to fold those proteins impacts their ability to evolve.

This presentation highlights high-resolution cryo-EM structures of C. albicans Cdr1 in various substrate-bound states, with and without nucleotides, resolved at 3.45–3.74 Å.

Rubisco is the most abundant protein on earth, catalysing photosynthetic CO2 fixation to provide all usable carbon in the biosphere. However, its slow and non-specific catalytic activity limits crop productivity and its resultant over-production represents a huge nitrogen cost.

Making key insights into antimalarial resistance mechanisms and delineate the utility of cutting-edge computational approaches that will go on to inform future drug design strategies and efforts.

Rust fungi are a diverse group of plant pathogens consisting of over 8,000 species in the Basidiomycete order Pucciniales. They parasitise numerous plants of agricultural and ecological importance, such as cereals, legumes, and trees.

The rust fungi (Pucciniales) comprise the largest order of plant pathogenic fungi and are among the most serious threats to both agricultural crops and natural ecosystems.

Over 50 years ago, the active principle 青蒿素 qīng hāo sū or artemisinin was isolated in pure crystal-line form from the leaves of the Chinese traditional herb 青蒿 qīng hāo - Artemisia annua - by Chinese groups working under the remarkable Project 523 during the latter stages of the Chinese Cultural Revolution.