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The increasing incidence of multi drug resistant malaria across the globe threatens the resurgence of one of humanities most devastating infectious disease. This resistance is often mediated by membrane transporter proteins, thwarting chemotheraputic interventions by transporting the drug molecules away from their site of action. But these membrane transporters may be the Malaria parasite's undoing; it's parasitic lifecycle has streamlined its transportome to a limited set of essential proteins that are ripe for molecular targeting. Projects in this area will seek to answer questions such as what is the structural basis of Malaria's multi drug resistance? Can we predict which drugs will be harder to evolve resistance to? How do drugs interact with their targets, and is it possible to design drug regimes which create evolutionary dead ends.