Fahrer Group - Immunology

Photo: Left to Right:Associate Professor Aude Fahrer, Dr. Christina Carroll and Dr. Erin Andrew

Photo: Left to Right: Dr. Lawrence Wilson, Associate Professor Aude Fahrer, Dr. Angelo Theodoratos, Dr. Katharine Gosling, Dr. Christina Carroll and Mr. Joshua Miasek

Photo: Left to Right: Mr.Andrew Almonte, Associate Professor Aude Fahrer, Mr. George Cavic

Photo: Left to Right: Mr. George Cavic, Mr. Andrew Almonte, Associate Professor Aude Fahrer and Ms. Ruth Purcell

About
Members
Projects
Publications
Stories & events

The Group is focused on two main areas of research at the moment:

A very simple and inexpensive cancer immunotherapy treatment I have come up with, involving a single injection of an immune stimulant into a tumour.
A bioinformatics study looking for novel proteins in different genomes. We have just recently around 2000 novel proteins from humans and mice.

The Fahrer Group is generously supported by the Lea Chapuis memorial fund. Read more, or donate here.

Infection and immunity

Evolutionary genetics and genomics

Bioinformatics and bio-mathematical modelling

Host-microbe biology

Group Leader

Aude Fahrer

Divisional Visitor

Kristine Hardy

Honours Students

PhB Students

PhD Student

George Cavic

Volunteer

Jo-Wai Wang

Project	Status
Chromosome condensation and T cell development	Current
Development of a simple, inexpensive therapeutic cancer vaccine	Current
Identification of 2000 novel protein isoforms in the human and mouse genomes	Current

Selected publications

Almonte AA, Cavic GC, Carroll SE, Neeman T & Fahrer AM. (2023) Early T cell infiltration correlates with anti-CTLA4 treatment response in murine cancer models. Journal of Immunology. https://doi.org/10.4049/jimmunol.210.Supp.172.02

Almonte, A, Cavic, G, Neeman, T, Enders, A, Fahrer, A.M. (2022) Gut microbiome-depleting antibiotic regimens are not tolerated by all mouse strains: learn from (our) bitter experience, Journal for ImmunoTherapy of Cancer, Volume 10, Issue 11.
Carroll, C, Andrew, E, Malik, L et al. (2021), Simple and effective bacterial-based intratumoral cancer immunotherapy, Journal for ImmunoTherapy of Cancer, vol. 9, no. 9.
Almonte, A, Rangarajan, H, Yip, D et al. (2020) How does the gut microbiome influence immune checkpoint blockade therapy?, Immunology and Cell Biology, 99: 361–372.
Wang, J, Gross, G, Andrew, E et al. (2019) A predicted novel protein isoform of HOXA9, Leukemia Research, 82:7-10.
Carroll, C, Altin, J, Neeman, T et al. (2015) Repeated fine-needle aspiration of solid tumours in mice allows the identification of multiple infiltrating immune cell types, Journal of Immunological Methods, 425:102-107.
Wilson L.O., Spriggs A, Taylor J.M., Fahrer A.M. (2014) A novel splicing outcome reveals more than 2000 new mammalian protein isoforms.Bioinformatics. Jan 15;30(2):151-6
Wilson, L.O; Fahrer, A.M. (2013) Condensins, chromatin remodeling and gene transcription, Chromatin Remodelling, Dr Danuta Radzioch (Ed.), ISBN: 978-953-51-1087-3 InTech. Also available from InTech Open
Fahrer, Aude M, (2012). A proposal for a simple and inexpensive therapeutic cancer vaccine, Immunology and Cell Biology 90 (3) 310-313
Theodoratos, Angelo; Wilson, Laurence O. W.; Gosling, Katharine M.; et al. (2012) Splice variants of the condensin II gene Ncaph2 include alternative reading frame translations of exon 1, Febs Journal 279 (8) 1422-1432
Theodoratos, A; Whittle, B; Enders, A; et al. (2010), Mouse strains with point mutations in TAP1 and TAP2, Immunology and Cell Biology 88 (1) 72-78
Gosling, KM; Goodnow, CC; Verma, NK; et al (2008), Defective T-cell function leading to reduced antibody production in a kleisin-beta mutant mouse, Immunology 125 (2) 208-217
Gosling, KM; Makaroff, LE; Theodoratos, A; et al (2007) A mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell development, Proceedings of the National Academy Of Sciences of the United States Of America 104 (30) 12445-12450
Liston, A; Lesage, S; Gray, DHD; et al, (2004) Generalized resistance to thymic deletion in the NOD mouse: A polygenic trait characterized by defective induction of Bim, Immunity 21 (6) 817-830
Fahrer, AM; Bazan, JF; Papathanasiou, P; et al (2001) A genomic view of immunology, Nature 409 (6822) 836-838
Fahrer, AM; Konigshofer, Y; Kerr, EM; et al,(2001) Attributes of gamma delta intraepithelial lymphocytes as suggested by their transcriptional profile, Proceedings of the National Academy Of Sciences of the United States Of America 98 (18) 10261-10266.