Corry Group - Transport proteins and computational biophysics

Our research examines the structure and function of a family of pore forming proteins known as ion channels. We use cutting edge computational methods to understand the mechanisms by which these and other membrane proteins can identify and transport molecules across the cell membrane, how the pores open and close to control this transport, and how they are influenced by the surrounding membrane. In addition we are interested in studying transport in other kinds of pores, be they in proteins, crystaline materials or synthetic membranes. Gaining a fundamental understanding of the operation of biological pores has allowed us to design synthetic porous membranes that can be used for the desalination of sea water or to remove dangerous contaminants from water supplies.

Proteins and macromolecules can be difficult to study due to their size, functioning at the interface of microscopic molecular behaviour and macroscopic mechanical behaviour. To investigate them we use a combination of computational techniques including quantum calculations, atomistic and coarse grained molecular dynamics, and macroscopic modelling. As experts in molecular simulation we apply our skills to help many other groups better understand the structure and function of their proteins of interest. In addition we utilise FRET microscopy (Förster Resonance Energy Transfer) to experimentally study the conformational changes of proteins as they function, and design computational codes to better design and interpret FRET experiments.

Members

Leader

Ben Corry

Ben Corry
Ben Corry graduated with a PhD in Physics from ANU, before taking up an ARC Postdoctoral Fellowship and subsequent ARC Research...

PhB Student

PhD Student

Postdoctoral Fellow

Special Project Student

Projects

Open to students

Publications

Publications

News & events

News

27
Feb
2018
New research from The Australian National University (ANU) has drilled down to the molecular level to find similarities across six pharmaceutical drugs used in pain relief, dentist anaesthetic, and treatment of epilepsy, in a bid to find a way to reduce unwanted side-effects.
05
Dec
2016
Ben Corry was awarded a grant from the Cancer Council of Western Australia, along with collaborators at UWA.
New insights into pain relief
04
Jul
2014
The precise knowledge of how the drug molecules attach to proteins in the nerve cell give a springboard for redesigning drugs without the side-effects that current drugs bring with them.

Highlights

Dr Ben Corry

Ben Corry

Following his passion for science, Ben Corry graduated with a PhD in Physics from ANU and is now a senior lecturer in the Research School of Biology.
Ben Corry at NCI

Meet Raijin, the local supercomputer at the National Computational Infrastructure

The ANU's super computer at the National Computational Infrastructure cost 50 million to build and 12 million a year to run.
Meet the Thought Leaders: Dr Ben Corry

Meet the Thought Leaders: Dr Ben Corry

Discover why ANU is such a fascinating place to be for young scientists.

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