Understanding the pathogenesis of the urinary tract pathogen Proteus mirabilis

Proteus mirabilis is a gram-negative bacterial species that is associated with nearly half of all catheter-associated urinary tract infections (CAUTIs). This species is exquisitely well equipped for colonising catheters due to its swarming ability, arsenal of fimbriae proteins, potent urease enzyme and other virulence factors.

This project aims to investigate proteins that are necessary for P. mirabilis pathogenesis as new potential anti-bacterial targets. Students on this project will be trained in protein biochemistry and structural biology methods.

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