Ion homeostasis in the malaria parasite

The aim of this project is to develop an integrated model for ion and cell volume homeostasis in the malaria parasite and its host red blood cell.

group Group
Kirk Group - Membrane transport in parasites
label Research theme
Host-microbe biology
Membrane transporters and channels
Parasitology
traffic Project status
Current

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About

A diagram illustrating the "Crossing boundaries - Molecular Interactions in Malaria" project, showing research methods, participating institutions and teams, divided into host and parasite focus areas, with an overlay of two circles representing collaboration.

The aim of this project is to develop an integrated model for ion and cell volume homeostasis in the malaria parasite and its host red blood cell.  The project will entail using a suite of physiological and biochemical techniques to characterize the mechanisms (channels, transporters, pumps) involved in ion regulation in the parasite (see Kirk, K. (2015). Ann. Rev. Microbiol., 69, 341–359).  The results will be incorporated into a quantitative computer model that will serve as an invaluable tool in understanding the mechanism of action of a growing number of ‘ion-disrupting’ antimalarial drugs.

This project is part of the Crossing Boundaries: Molecular Interactions in Malaria Graduate School. Participants study at both ANU and the Humboldt University in Berlin, earning a dual degree. Find out more.

Photo contribution: James Walsh. Graphic contribution: Kiaran Kirk.

Members

Supervisor

Kiaran Kirk

Dean
ANU College of Science and Medicine

Researcher

Adele Lehane