Broer Group - Membrane transport and nutrition

Nutrients are essential for the growth and maintenance of cells and organisms. Membrane transporters are essential to deliver nutrients to cells and tissues and thus play a significant role in the regulation of metabolism. We study the role of amino acid transport in the onset of insulin resistance and the regulation of carbohydrate metabolism. Amino acid transport is crucial for growing cells and thus is a target to curtail cancer growth. We are investigating in how far amino acid transport in cancer cells is different from normal cells. In addition to amino acid transport we investigate the role of phospholipid transport in cell development and signalling in the immune system.

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Selected publications

  • Bröer A, Rahimi F, Bröer S. Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells. J Biol Chem. 2016 Apr 26.
  • Jiang Y, Rose AJ, Sijmonsma TP, Bröer A, Pfenninger A, Herzig S, Schmoll D, Bröer S. Mice lacking neutral amino acid transporter B(0)AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control. Mol Metab. 2015; 4(5):406-17.
  • Tumer, E., Broer, A., Balkrishna, S., Julich, T. and Broer, S. (2013) Enterocyte-specific regulation of the apical nutrient transporter SLC6A19 (B(0)AT1) by transcriptional and epigenetic networks. The Journal of biological chemistry. 288, 33813-33823
  • Yabas, M., Teh, C. E., Frankenreiter, S., Lal, D., Roots, C. M., Whittle, B., Andrews, D. T., Zhang, Y., Teoh, N. C., Sprent, J., Tze, L. E., Kucharska, E. M., Kofler, J., Farell, G. C., Broer, S., Goodnow, C. C. and Enders, A. (2011) ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes. Nat Immunol. 12, 441-449
  • Broer, S. and Palacin, M. (2011) The role of amino acid transporters in inherited and acquired diseases. Biochem J. 436, 193-211
  • Kowalczuk, S., Broer, A., Tietze, N., Vanslambrouck, J. M., Rasko, J. E. and Broer, S. (2008) A protein complex in the brush-border membrane explains a Hartnup disorder allele. Faseb J. 22, 2880-2887
  • Seow, H. F., Broer, S., Broer, A., Bailey, C. G., Potter, S. J., Cavanaugh, J. A. and Rasko, J. E. (2004) Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19. Nat Genet. 36, 1003-1007
  • Broer, A., Klingel, K., Kowalczuk, S., Rasko, J. E., Cavanaugh, J. and Broer, S. (2004) Molecular Cloning of Mouse Amino Acid Transport System B0, a Neutral Amino Acid Transporter Related to Hartnup Disorder. J Biol Chem. 279, 24467-24476.

All publications

Forward genetic screening identifies a link between Plasmodium falciparum fever response, artemisinin resistance and the algal origins of the apicoplast

Event | Mon 2 March 2020
The emergence and spread of Plasmodium falciparum parasites that are resistant to front-line antimalarial artemisinin-combination therapies (ACT) threatens to erase the considerable gains against the disease of the last decade. We developed a new large-scale phenotypic screening pipeline and used it to carry out the fi

Can humanised bacterial LeuT be used to study the pharmacology of human B0AT1 (SLC6A19)?

Event | Thu 14 November 2019
The amino acid transporter B0AT1 (SLC6A19) has recently been identified as a possible target to treat type 2 diabetes, phenylketonuria and related disorders.
PhD student, Javed Kiran

Development of biomarkers for the inhibition of SLC6A19 – a potential target to treat metabolic disorders

Event | Thu 14 November 2019
With the help of these biomarkers, we also evaluated the efficacy of four different SLC6A19 inhibitors biomarkers in wild type mice with metabolic disorders.
Dr Diana Stojanovski, University of Melbourne

Mitochondrial Protein Import in Health and Disease

Event | Thu 17 October 2019
Mitochondrial function and cell viability require a functional and healthy mitochondrial proteome.

Nrf2/Keap1 and diabetes: an opportunity for drug discovery?

Event | Thu 7 March 2019

Chronic oxidative stress has been postulated to drive insulin resistance and diabetic complications.

BSB PhD Exit Seminar: Phospholipid Flippases in B cells and Platelets

Event | Thu 22 February 2018

Phosphatidylserine (PS) is predominantly confined to the inner leaflet of the plasma membrane in eukaryotes through the action of ATP-dependent pho

Bacterial lipid trafficking and outer membrane homeostasis.

Event | Tue 13 February 2018

Gram-negative bacteria can survive in harsh environments in part because of the presence of the outer membrane (OM), which comprises lipopolysaccha

Professor Stefan Bröer

'Compounds ANU' forges bonds between chemistry, biology and medical research

Story | Thursday 11 April 2019
Stefan Bröer is looking for the right molecule for a biological target, that could be developed into a drug to treat diabetes. Now ANU has its own library of compounds, available to biological and medical researchers, managed by the Research School of Chemistry.

ARC grant success

Story | Friday 10 November 2017
The Australian National University (ANU) has won $24 million in Australian Research Council (ARC) funding for 58 research projects across the University. 

How a rare disorder can lead to possible treatments for type 2 diabetes

Story | Thursday 9 February 2017
Hartnup disorder is a rare disorder that is caused by an inability to absorb the breakdown products of protein digestion, namely amino acids. In 2004, Stefan Bröer’s group discovered the gene that is mutated in Hartnup disorder, a transporter that mediates the absorption of amino acids in the intestine and kidney.

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