Carol Behm

Group membership

Carolyn Behm received a BSc (Hons) in Cell Biology and Zoology and a PhD from The Australian National University, in which she studied biochemistry of tapeworms. After several years' teaching and research at the University of Malaya, she returned to the Department of Zoology at The Australian National University to investigate biochemistry of helminth parasites. In 1987 Dr Behm commenced a lectureship in the Department of Biochemistry, where she taught cell biology and biochemistry while continuing research in helminth biochemistry and host pathophysiology. She held an ARC Senior Research Fellowship from 1992-1997. In recent years Dr Behm's research has focussed on aspects of nematode molecular biology, using the powerful model organism, Caenorhabditis elegans.

Research interests

Molecular genetics and functional genomics of nematodes.

Recent grants

  • 2011-2013 Commercialisation Australia 'Development of an in vitro assay of a new anti-nematode drug target' $50,000 (C.A. Behm)
  • 2011-2012 Discovery Translation Fund, ANU Connect Ventures 'Development and evaluation of an in vitro nematode permeability assay to discover new classes of anti-nematode drugs' $99,625 (C.A. Behm)
  • 2007 – 2010 Australian Wool Innovation Ltd/Meat and Livestock Australia Ltd ‘Identification and validation of new drug targets for control of gastrointestinal nematode parasites of sheep’ $1,936,744 (C.A. Behm, J. Zawadzki, A. Kotze)
  • 2006 – 2010 Grains Research & Development Corporation ‘Exploring a model system to develop controls for plant parasitic nematodes’ $424,000 (C.A. Behm, S. Trowell, U. Mathesius)
  • 2006 – 2009 CSIRO Food Futures Flagship Cluster Collaboration ‘Learning the principles of olfactory pattern recognition from insects and nematodes’ $2,080,364 (M. Srinivasan, J. Reinhard, C. Claudianos, C. Warr, C. Behm, U. Mathesius).
  • Somasiri, P, Behm, C, Adamski, M et al. 2020, 'Transcriptional response of Caenorhabditis elegans when exposed to Shigella flexneri', Genomics, vol. 112, pp. 774-781.
  • Chin, S, Behm, C & Mathesius, U 2018, 'Functions of Flavonoids in Plant-Nematode interactions', Plants, vol. 7, no. 4, 85.
  • George, D, Mathesius, U, Behm, C et al 2014, 'The Periplasmic Enzyme, AnsB, of Shigella flexneri Modulates Bacterial Adherence to Host Epithelial Cells', PLOS ONE (Public Library of Science), vol. 9, no. 4, pp. e94954-e94954.
  • George, D, Behm, C, Hall, D et al 2014, 'Shigella flexneri infection in Caenorhabditis elegans: Cytopathological examination and identification of host responses', PLOS ONE (Public Library of Science), vol. 9, no. 9, pp. e106085-e106085.
  • Duan, G, Saint, R, Helliwell, C et al. 2013, 'C-elegans RNA-dependent RNA polymerases rrf-1 and ego-1 silence Drosophila transgenes by differing mechanisms', Cellular and Molecular Life Sciences, vol. 70, no. 8, pp. 1469-1481.
  • Zawadzki, J, Kotze, A, Fritz, J et al. 2012, 'Silencing of essential genes by RNA interference in Haemonchus contortus', Parasitology, vol. 139, no. 5, pp. 613-629.
  • Knight, A, Johnson, N & Behm, C 2012, 'VHA-19 is essential in Caenorhabditis elegans Oocytes for embryogenesis and is involved in trafficking in oocytes', PLOS ONE (Public Library of Science), vol. 7, no. 7.
  • Behm, C & Knight, A 2012, 'Minireview: The role of the vacuolar ATPase in nematodes', Journal of Parasitology, vol. 132, pp. 47-55.
  • Hayward, D, Hetherington, S, Behm, C et al 2011, 'Differential Gene Expression at Coral Settlement and Metamorphosis - A Subtractive Hybridization Study', PLOS ONE (Public Library of Science), vol. 6, no. 10, pp. e26411-e26411.
  • Hayward, D, Hetherington, S, Behm, C et al 2011, 'Differential Gene Expression at Coral Settlement and Metamorphosis - A Subtractive Hybridization Study', PLOS ONE (Public Library of Science), vol. 6, no. 10, pp. e26411-e26411.
  • Behm, C, Fritz, J, Hetherington, S, Zawadzki, J 2009, Anthelmintic agents. Australian Patent Appl. No. 2009904881, filed 7 October 2009; PCT/AU/2010/001317; WO 2011/041839 A1, published 14 April 2011.
  • Hetherington, S, Gally, C, Fritz, J et al 2011, 'PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis', Developmental Biology, vol. 350, no. 2, pp. 267-278.
  • Ponton, F, Lalubin, F, Fromont, C et al 2011, 'Hosts use altered macronutrient intake to circumvent parasite-induced reduction in fecundity', International Journal for Parasitology, vol. 41, no. 1, pp. 43-50.
  • Hassan, S, Behm, C & Mathesius, U 2010, 'Effectors of plant parasitic nematodes that re-program root cell development', Functional Plant Biology, vol. 37, no. 10, pp. 933-942.
  • Duan, G, Saint, R, Helliwell, C et al 2010, 'Expression of Caenorhabditis elegans RNA-directed RNA polymerase in transgenic Drosophila melanogaster does not affect morphological development', Transgenic Research, vol. 19, pp. 1121-1128.
  • Fritz, J & Behm, C 2009, 'CUTI-1: A novel tetraspan protein involved in C. elegans CUTicle formation and epithelial Integrity', PLoS ONE (Public Library of Science), vol. 4, no. 4, pp. e5117.
  • Johnson, N, Fritz, J & Behm, C 2008, 'RNAi in Caenorhabditis elegans', in Tim Doran & Chris Helliwell (ed.), RNA Interference: Methods for Plants and Animals, CABI Publishing, UK, pp. 85-113.
  • Grant, W & Behm, C 2007, 'Target identification and validation for anthelmintic discovery', Expert Opinion on Drug Discovery, vol. 2, no. S1, pp. 1-8.
  • Behm, C, Bendig, M, McCarter, J et al 2005, 'RNAi-based discovery and validation of new drug targets in filarial nematodes', Trends in Parasitology, vol. 21, no. 3, pp. 97-100.
  • Johnson, N, Behm, C & Trowell, S 2005, 'Heritable and inducible gene knockdown in C. elegans using Wormgate and the ORFeome', Gene, vol. 359, pp. 26-34.
  • Archer, S, Behm, C, Claudianos, C et al 2004, 'The Flightless I protein and the gelsolin family in nuclear hormone receptor-mediated signalling', Biochemical Society Transactions, vol. 32, no. 6, pp. 940-942.
  • Pellerone, F, Archer, S, Behm, C et al. 2003, 'Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes', International Journal for Parasitology, vol. 33, no. 11, pp. 1195-1206.
  • Walker, G, Geue, R, Sargeson, A, Behm, C 2003, 'Surface-active cobalt cage complexes: synthesis, surface chemistry, biological activity, and redox properties', Dalton Transactions, vol. 15, pp. 2992-3001.
  • Behm, C 2002, 'Metabolism', in Donald L Lee (ed.), The Biology of Nematodes, Taylor & Francis Group, London, pp. 261-290.
  • Lenton, L & Behm, C 2000, 'Hepatic Cell Function in Liver Fluke Infection', in Zimmer, Guido (ed.), Membrane Structure in Disease and Drug Therapy, Marcel Dekker Inc., New York, U.S.A., pp. 201-215.
  • Behm, C & Ovington, K, 2000, 'The Role of Eosinophils in Parasitic Helminth Infections: Insights from Genetically Modified Mice', Parasitology Today, vol. 16, pp. 202-209.
  • Behm, C, & Sangster, N 1999 'Pathology, pathophysiology and clinical aspects.' In: Fasciolosis (Dalton, J, Ed), CAB International, London, pp.185-224.
  • Page-Sharp, M, Behm, C & Smith, G 1999, 'Involvement of the compatible solutes trehalose and sucrose in the response to salt stress of a cyanobacterial Scytonema species isolated from desert soils', Biochimica et Biophysica Acta: International journal of Biochemistry and Biophysics, vol. 1472, pp. 519-528.

Carol supervises PhB ASC, undergraduate and Honours research projects.