Functional genomics of C. elegans to identify and validate new antinematode drug targets.
Parasitic nematodes are important because of the mortality and misery they cause to people and the considerable damage they do to agriculture. The current control measures for important nematode parasites are failing because parasite populations have become resistant to all the major classes of anthelmintic drugs that are commercially available. In order to design more effective control measures, we need to identify molecular targets for the development of new anti-nematode drugs. My lab is currently using functional genomics of C. elegans to discover and validate new anti-nematode drug targets.