ABSTRACT/BIOGRAPHY

Matt is a Senior Lecturer at the University of Sydney and leads the Laboratory of Bacterial Outer Membrane Biogenesis (BOMB). His laboratory focuses on the incredibly multifunctional Omp85 protein superfamily which conduct essential processes in the outer membranes of all Gram-negative bacteria such as protein folding, insertion, and translocation reactions, as well as lipid transport reactions. His laboratory also discovers novel inhibitors that can arrest these proteins at defined steps of the reaction mechanism allowing their study. Although the inhibitors are useful tools to study these important proteins, they are also being developed as novel antibiotics, resistance breakers, and anti-virulence compounds.