Engineering the secretory pathways of yeast

Insulin secretion pathway

Yeast fermentation is a multi-billion dollar global industry, at the basis of many new Synthetic Biology companies. A key aspect of this technology is being able to efficiently excrete high value protein products from the yeast cells which significantly simplifies downstream purification.


This project seeks to engineer a universal secretion system for Saccharomyces cerevisiae, which can be applied to any protein targeted for secretion with high efficiency.