Contacts
Contact email:david.jones@anu.edu.au
Contact phone:+61 2 6125 4192 (Office)
Location:Rm 3.092, Level 3, Linnaeus Building (134)
Centre:Division of Plant Sciences
Group membership
Group Leader, Jones Group - Disease resistance
David Jones obtained his B.Sc. (Hons) and PhD at the Department of Genetics, University of Adelaide working on the genetics of the interaction between flax and the flax rust fungus Melampsora lini. He was then awarded a Charles John Everard Postdoctoral Fellowship in the Department of Plant Pathology, Waite Agricultural Research Institute, University of Adelaide where he worked on the biological control of crown gall. His work led to the first commercial release of a genetically modified bacterium, subsequently marketed as NoGall. He was then offered a postdoctoral fellowship in The Sainsbury Laboratory, John Innes Centre, Norwich, where he worked on the genetic and molecular basis of the interaction between tomato and the leaf mould fungus Cladopsorium fulvum. His work led to the isolation of the tomato Cf-9 gene, one of the first plant disease resistance genes cloned. In 1996, he returned to Australia to set up his own lab in the Research School of Biological Sciences (now the Research School of Biology) at The Australian National University, where he continues work on the molecular basis of disease and disease resistance in tomato (leaf mould and Fusarium wilt) and flax (flax rust).
Research interests
- Protein trafficking
- Plant physiology
- Signal transduction
- Gene expression (incl. microarray and other genome-wide approaches)
- Genome structure and regulation
- Receptors and membrane biology
- Plant cell and molecular biology
- Plant pathology
- Genetics
Recent grants
- Dr David Jones and Dr Peter Dodds (CSIRO Plant Industry) ARC Discovery 2012-2014 Isolation and functional characterisation of a pathogen meta effector able to inhibit detection of multiple disease effectors by resistant plants, $340K
- Dr Ann-Maree Catanzariti and Dr Martijn Rep (University of Amsterdam) ARC Discovery - APD 2010-2012 Pathogen recognition and plant defence activation by a novel Fusarium wilt resistance protein from tomato, $330K
- Professor Adrienne Hardham, Dr David Jones, Dr Peter Dodds (CSIRO Plant Industry) and Dr Jeff Ellis (CSIRO Plant Industry) ARC Discovery 2010-2012 Role of fungal secreted proteins as plant disease effectors $330K
- Dr David Jones and Mr Des McGrath (Queensland Department of Primary Industries and Fisheries) ARC Linkage - PhD Studentship 2010-2012 Protecting tomato crops from Fusarium wilt through the efficient application of new genetic resources. $80K.
Projects
- Supervisor, Fungal effector uptake into plant cells
- Supervisor, Identification and functional characterisation of flax rust effectors
- Supervisor, Use of a tobacco Pathogenesis-related Protein-5 (PR-5) promoter: β glucuronidase (GUS) reporter system to study plant defence activation in response to phytohormones, abiotic stresses and biotic inducers.
- Collaborator, The molecular basis for plant susceptibility and immunity to Fusarium wilt disease
- Researcher, Fungal effector uptake into plant cells
Selected publications
- Anderson, C., Khan, M.A., Catanzariti, A-M., Jack, C.A., Nemri, A., Lawrence, G.J., Upadhyaya, N.M., Hardham, A.R., Ellis, J.G., Dodds, P.N. and Jones, D.A. 2016. Genome analysis and avirulence gene cloning using a high-density RADseq linkage map of the flax rust fungus, Melampsora lini. BMC Genomics 17: 667
- Chakrabarti, A., Velusamy, T., Tee, C.Y. and Jones, D.A. 2016. A mutational analysis of the cytosolic domain of the tomato Cf-9 disease-resistance protein shows that membrane-proximal residues are important for Avr9-dependent necrosis. Molecular Plant Pathology 17: 565-576
- Gonzalez-Cendales, Y., Catanzariti, A.-M., Baker, B., McGrath, D.J. and Jones, D.A. 2016. Identification of I-7 expands the repertoire of genes for resistance to Fusarium wilt in tomato to three resistance gene classes. Molecular Plant Pathology 17: 448-463
- Catanzariti, A.-M., Lim, G.T.T. and Jones, D.A. 2015. The tomato I-3 gene: a novel gene for resistance to Fusarium wilt disease. New Phytologist 207: 106-118
- Nemri, A., Saunders, D. G. O., Anderson, C., Uphadyaya, N. M., Win, J., Jones, D. A., Kamoun, S., Ellis, J. G. and Dodds, P. N. 2014. Genome and effector complement of the flax rust pathogen (Melampsora lini). Frontiers in Plant Science 5: 98
- Ve, T., Williams, S., Catanzariti, A.-M., Rafiqi, M., Rahman, M., Ellis, J. G., Hardham, A. R., Jones, D. A., Anderson, P. A., Dodds, P. N. and Kobe, B. 2013. Structures of the flax rust effector AvrM reveal insights into the molecular basis of host-cell entry and effector-triggered immunity. Proceedings of the National Academy of Sciences USA 110, 17594-17599
- Takemoto, D., Rafiqi, M., Hurley, U., Lawrence, G.J., Bernoux, M., Hardham, A.R., Ellis, J.G., Dodds, P.N. and Jones, D.A. 2012. N-terminal motifs in some plant disease resistance proteins function in membrane attachment and contribute to disease resistance. Molecular Plant-Microbe Interactions 25:379-392.
- Rafiqi, M., Gan, P.H.P., Ravensdale, M., Lawrence, G.J., Ellis, J.G., Jones, D.A., Hardham, A.R., and Dodds, P.N. 2010. Internalization of flax rust avirulence proteins into flax and tobacco cells can occur in the absence of the pathogen. Plant Cell 22:2017-2032.
- Wulff, B.B.H., Chakrabarti, A., and Jones, D.A. 2009. Recognitional specificity and evolution in the tomato-Cladosporium fulvum pathosystem. Molecular Plant-Microbe Interactions 22:1191-1202.
- Chakrabarti, A., Panter, S.N., Harrison, K., Jones, J.D.G., and Jones, D.A. 2009. Regions of the Cf-9B disease resistance protein able to cause spontaneous necrosis in Nicotiana benthamiana lie within the region controlling pathogen recognition in tomato. Molecular Plant-Microbe Interactions 22:1214-1226.
- Wulff, B.B., Heese, A., Tomlinson-Buhot, L., Jones, D.A., de la Peña, M., and Jones, J.D.G. 2009. The major specificity-determining amino acids of the tomato Cf-9 disease resistance protein are at hypervariable solvent-exposed positions in the central leucine-rich repeats. Molecular Plant-Microbe Interactions 22:1203-1213
- Lim, G.T.T., Wang, G.P., Hemming, M.N., McGrath, D.J., and Jones, D.A. 2008. High resolution genetic and physical mapping of the I-3 region of tomato chromosome 7 reveals almost continuous microsynteny with grape chromosome 12 but interspersed microsynteny with duplications on Arabidopsis chromosomes 1, 2 and 3. Theoretical and Applied Genetics 118:57-75.
- Barker, C.L., Talbot, S.J., Jones, J.D.G., and Jones D.A. 2006. A tomato mutant that shows stunting, wilting, progressive necrosis and constitutive expression of defense genes contains a recombinant Hcr9 gene encoding an autoactive protein. Plant Journal 46:369-384.
- Barker, C.L., Baillie, B.K., Hammond-Kosack, K.E., Jones, J.D.G., and Jones, D.A. 2006. Dominant-negative interference with defence signalling by truncation mutations of the tomato Cf-9 disease resistance gene. Plant Journal 46:385-399.
- Takemoto, D., and Jones, D.A. 2005. Membrane release and destabilization of Arabidopsis RIN4 following cleavage by Pseudomonas syringae AvrRpt2. Molecular Plant-Microbe Interactions 18: 1258-1268.
- Benghezal, M., Wasteneys, G.O., and Jones, D.A. 2000. The C-terminal dilysine motif confers endoplasmic reticulum localization to type I membrane proteins in plants. Plant Cell 12:1179-1201.
- Jones, D.A., Thomas, C.M., Hammond-Kosack, K.E., Balint-Kurti, P.J., and Jones, J.D.G. 1994.Isolation of the tomato Cf-9 gene for resistance to Cladosporium fulvum by transposon tagging. Science 266:789-793
All publications
Convenor and lecturer in BIOL3177 Advances in Molecular Plant Science and BIOL3106 Biosecurity
