Stefan Broer

Contacts

Contact email:stefan.broeer@anu.edu.au
Contact phone:+61 2 6125 2540 (Office)
Location:Rm 2.014, Level 2, Linnaeus Building (134)
Centre:Division of Biomedical Science and Biochemistry
Link:ANU Researchers profile

Group membership

Group Leader, Broer Group - Membrane transport and nutrition

Stefan studied Biochemistry at the University of Tuebingen/Germany from 1981 to 1986. He completed his Masters in 1987 and moved to the Research Center in Juelich where he worked on amino acid producing bacteria during his PhD. He was awarded his PhD in 1991 and moved to the University of Illinois in Chicago as a research fellow of the German Science Foundation. In 1993 he was appointed as Junior Lecturer at the University of Tuebingen in the Institute of Physiological Chemistry. In 1998 Stefan was promoted to Senior Lecturer and moved to the Institute of Physiology at the University of Tuebingen. In 2000 Stefan moved to ANU as a Senior Lecturer in the School of Biochemistry and Molecular Biology. He was promoted to Associate Professor in 2006 and to full Professor in 2008. Stefan was treasurer and council member of the Australian Physiological Society from 2005-2009.

Research interests

Membrane transporters in health and disease.

Recent grants

  • Broer, S. and A. Enders. (2014) AUD 440,172, 3 years, Phospholipid dependent signaling in B-cells, NHMRC, Project Grant GNT1061288
  • Broer, S. (2013) AUD 637,131, 3 years, SLC6A19 - Human target validation and assay generation, Sanofi-Aventis, Sponsored research 
  • Broer, S. (2012) AUD 50,540, 2 years, The role of amino acids in insulin resistance, Sanofi-Aventis, Sponsored research 
  • Broer, S. (2011) AUD 120,000, Real time monitor for cell growth and motility, The Australian National University, Major Equipment Grant 11MEC23
  • Broer, S., et al. (2010) AUD 379,125, 3 Years, The role of the glutamine transporter SNAT3 in ion transport, cell signaling and ammonia detoxification, NHMRC, Project Grant 585479
  • Broer, S. (2009) AUD 284250, 3 Years, Metabolic complexes of the brush-border membrane, NHMRC, Project Grant 284250.

Projects

  • Gauthier-Coles, G, Fairweather, S, Broer, A et al. 2023, 'Do Amino Acid Antiporters Have Asymmetric Substrate Specificity?', Biomolecules, vol. 13, no. 2, pp. 1-19.
  • Cuny, H, Bozon, K, Kirk, R et al. 2022, 'Maternal heterozygosity of Slc6a19 causes metabolic perturbation and congenital NAD deficiency disorder in mice', Disease Models and Mechanisms, vol. 16, no. 5, pp. 1-13.
  • Broer, S 2022, 'Amino acid transporters as modulators of glucose homeostasis', Trends in Endocrinology and Metabolism, vol. 33, no. 2, pp. 120-135.
  • Broer, S & Gauthier-Coles, G 2022, 'Amino Acid Homeostasis in Mammalian Cells with a Focus on Amino Acid Transport', Journal of Nutrition, vol. 152, no. 1, pp. 16-28.
  • Paulusma, C, Lamers, W, Broer, S et al. 2022, 'Amino acid metabolism, transport and signalling in the liver revisited', Biochemical Pharmacology, vol. 201.
  • Das, A, Gauthier-Coles, G, Broer, S et al. 2022, 'Impact of Inhibition of Glutamine and Alanine Transport on Cerebellar Glial and Neuronal Metabolism', Biomolecules, vol. 12, no. 9.
  • Navarro-Garrido, A, Kim, Y, Oe, Y et al. 2022, 'Aristolochic acid-induced nephropathy is attenuated in mice lacking the neutral amino acid transporter B0AT1 (Slc6a19)', American Journal of Physiology - Renal Physiology, vol. 323, no. 4, pp. F455-F467.
  • Gauthier-Coles, G, Broer, A, McLeod, M et al. 2022, 'Identification and characterization of a novel SNAT2 (SLC38A2) inhibitor reveals synergy with glucose transport inhibition in cancer cells', Frontiers in Pharmacology, vol. 13.
  • Fairweather, S, Okada, S, Gauthier-Coles, G et al. 2021, 'A GC-MS/Single-Cell Method to Evaluate Membrane Transporter Substrate Specificity and Signaling', Frontiers in Molecular Biosciences, vol. 8, pp. 1-21.
  • Fraser, M, Jing, W, Broer, S et al. 2021, 'Breakdown in membrane asymmetry regulation leads to monocyte recognition of P. falciparum-infected red blood cells', PLoS Pathogens, vol. 17, no. 2.
  • Gauthier-Coles, G, Vennitti, J, Zhang, Z et al. 2021, 'Quantitative modelling of amino acid transport and homeostasis in mammalian cells', Nature Communications, vol. 12, no. 5282.
  • Waters, M, Delghingaro-Augusto, V, Javed, K et al. 2021, 'Knockout of the Amino Acid Transporter SLC6A19 and Autoimmune Diabetes Incidence in Female Non-Obese Diabetic (NOD) Mice', Metabolites, vol. 11, no. 665.
  • Alexander, S, Kelly, E, Mathie, A et al. 2021, 'The Concise Guide to PHARMACOLOGY 2021/22: Transporters', British Journal of Pharmacology, vol. 178, no. S1, pp. S412-S513.
  • Fairweather, S, Rajendran, E, Blume, M et al. 2021, 'Coordinated action of multiple transporters in the acquisition of essential cationic amino acids by the intracellular parasite Toxoplasma gondii, PLoS Pathogens, 17, https://doi.org/10.1371/journal.ppat.1009835
  • Yadav, A, Shah, N, Tiwari, P et al. 2020, 'Novel Chemical Scaffolds to Inhibit the Neutral Amino Acid Transporter B0AT1 (SLC6A19), a Potential Target to Treat Metabolic Diseases', Frontiers in Pharmacology, vol. 11, pp. -.
  • Broer, S 2020, 'Amino Acid Transporters as Targets for Cancer Therapy: Why, Where, When, and How', International Journal of Molecular Sciences, vol. 21, no. 17, pp. 1-20.
  • Yap, Y, Rusu, P, Chan, A et al. 2020, 'Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution', Nature Communications, vol. 11, no. 2894, pp. 1-13.
  • Fairweather, S, Shah, N & Broer, S 2020, 'Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology', in JD Ash, RE Anderson, M LaVail, C Bowes Rickman, JG Hollyfield, C Grimm (ed.), Advances in Experimental Medicine and Biology, Springer Singapore, Singapore, pp. 1 - 115.
  • Zhang, V, Kucharski, R, Landers, C et al 2019, 'Characterization of a Dopamine Transporter and Its Splice Variant Reveals Novel Features of Dopaminergic Regulation in the Honey Bee', Frontiers in Physiology, vol. 10, pp. -.
  • Javed, K, Javed, K, Broer, S et al 2019, 'Mice lacking the intestinal and renal neutral amino acid transporter slc6a19 demonstrate the relationship between dietary protein intake and amino acid malabsorption', Nutrients, vol. 11, no. 9.
  • Javed, K, Javed, K, Broer, S et al 2019, 'Mice lacking the intestinal and renal neutral amino acid transporter slc6a19 demonstrate the relationship between dietary protein intake and amino acid malabsorption', Nutrients, vol. 11, no. 9.
  • Broer, S & Fairweather, S 2019, 'Amino Acid Transport Across the Mammalian Intestine', Comprehensive Physiology, vol. 9, no. 1, pp. 343-373pp.
  • Parker, K *, Fairweather, S *, Rajendran, E et al. 2019, 'The tyrosine transporter of Toxoplasma gondii is a member of the newly defined apicomplexan amino acid transporter (ApiAT) family', PLoS Pathogens, 15, e1007577.
    * Co-first authors
  • Jing, W, Yabas, M, Broer, A et al 2019, 'Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in platelets', Blood Advances, vol. 3, no. 3, pp. 219-229pp.
  • Broer, S 2018, 'Amino Acid Transporters as Disease Modifiers and Drug Targets', SLAS Discovery, vol. 23, no. 4, pp. 303-320pp.
  • Dong, W, Todd, A, Broer, A et al 2018, 'PKC-Mediated Modulation of Astrocyte SNAT3 Glutamine Transporter Function at Synapses in Situ', International Journal of Molecular Sciences, vol. 19, no. 924, pp. 13pp.
  • Broer, A, Fairweather, S & Broer, S 2018, 'Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets', Frontiers in Pharmacology, vol. 9, no. 785, pp. 1-11pp.
  • Javed, K, Cheng, Q, Carroll, A et al 2018, 'Development of Biomarkers for Inhibition of SLC6A19 (B0AT1)-A Potential Target to Treat Metabolic Disorders', International Journal of Molecular Sciences, vol. 19, no. 11, pp. 22pp.
  • Broer, A, Gauthier-Coles, G, Rahimi, F et al. 2018, 'Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells', Journal of Biological Chemistry, vol. 294, pp. 4012-4026.
  • Alexander, S, Kelly, E, Marrion, N et al 2017, 'THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview', British Journal of Pharmacology, vol. 174.
  • Cheng, Q, Shah, N, Broer, A et al. 2017, 'Identification of novel inhibitors of the amino acid transporter B0AT1 (SLC6A19), a potential target to induce protein restriction and to treat type 2 diabetes', British Journal of Pharmacology, vol. 174, no. 6, pp. 468-482pp.
  • Broer, S & Broer, A 2017, 'Amino acid homeostasis and signalling in mammalian cells and organisms', Biochemical Journal, vol. 474, no. 12, pp. 1935-1963.
  • Masle-Farquhar, E, Broer, A, Yabas, M, Enders*, A and S. Broer* (*equal contribution). 2017, 'ASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production.', Frontiers in Immunology, vol. 8, no. 549, pp. 1-11.
  • Rajendran, E, Hapuarachchi, S, Miller, C et al 2017, 'Cationic amino acid transporters play key roles in the survival and transmission of apicomplexan parasites', Nature Communications, 8:14455. doi: 10.1038/ncomms14455.
  • Todd, A, Marx, M, Hulme, S et al 2017, 'SNAT3-mediated glutamine transport in perisynaptic astrocytes in situ is regulated by intracellular sodium', Glia, vol 65(6), pp. 900-916pp.
  • Broer, A, Rahimi, F & Broer, S 2016, 'Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells', Journal of Biological Chemistry, vol. 291, no. 25, pp. 13194-13205.
  • Broer, S, Vandenberg, R & Ryan, R 2016, 'Brain transporters: From genes and genetic disorders to function and drug discovery', Neurochemistry International, vol. 98, pp. 1-3.
  • Chan, K, Busque, S, Sailer, M et al 2016, 'Loss of function mutation of the Slc38a3 glutamine transporter reveals its critical role for amino acid metabolism in the liver, brain, and kidney', Pflugers Archives European Journal of Physiology, vol. 468, no. 2, pp. 213-227.
  • Yabas, M, Jing, W, Shafik, S, Bröer S and A. Enders. 2016, 'ATP11C facilitates phospholipid translocation across the plasma membrane of all leukocytes', PLOS ONE (Public Library of Science), 2016 Jan 22;11(1):e0146774
  • Alexander, S, Kelly, E, Marrion, N et al 2015, 'THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: OVERVIEW', British Journal of Pharmacology, vol. 172, no. 24, pp. 5729-5743.
  • Rae, C & Broer, S 2015, 'Creatine as a booster for human brain function. How might it work?', Neurochemistry International, vol. 89, no. 2015, pp. 249-259.
  • Elso, C, Chu, E, Alsayb, M et al 2015, 'Sleeping Beauty Transposon Mutagenesis as a Tool for Gene Discovery in the NOD Mouse Model of Type 1 Diabetes', G3: Genes, Genomes, Genetics, vol. 5, no. 12, pp. 2903-2911pp.
  • Morton, S, Chaston, D, Howitt, L et al 2015, 'Loss of functional endothelial connexin40 results in exercise-induced hypertension in mice', Hypertension, vol. 65, no. 3, pp. 662-U362.
  • Jiang, Y, Rose, A, Sijmonsma, T et al 2015, 'Mice lacking neutral amino acid transporter B0AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control', Molecular Metabolism, vol. 4, no. 5, pp. 406-417.
  • Alexander, S, Kelly, E, Marrion, N et al 2015, 'THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Transporters', British Journal of Pharmacology, vol. 172, no. 24, pp. 6110-6202pp.
  • Fairweather, S, Broer, A, Subramanian, N, Tumer, E, Cheng, Q, Schmoll, D, O'Mara, ML, Bröer, S. 2015, 'Molecular basis for the interaction of the mammalian amino acid transporters B0AT1 and B0AT3 with their ancillary protein collectrin', Journal of Biological Chemistry, vol. 290, no. 40, pp. 24308-24325.
  • Balkrishna, S, Broer, A, Welford, S et al 2014, 'Expression of glutamine transporter Slc38a3 (SNAT3) during acidosis is mediated by a different mechanism than tissue-specific expression', Cellular Physiology and Biochemistry, vol. 33, no. 5, pp. 1591-1606.
  • Broer, S 2014, 'The SLC38 family of sodium-amino acid co-transporters', Pflugers Archives European Journal of Physiology, vol. 466, no. 1, pp. 155-172.
  • Yabas, M, Coupland, L.A., Cromer, D., Winterberg, M., Teoh, N.C. D'Rozario, J., Kirk, K., Bröer, S., Paris, C.R. and A. Enders 2014, 'Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span', Journal of Biological Chemistry, 289, 19531-19537.
  • Krokowski, D, Han, J, Saikia, M et al 2013, 'A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux', Journal of Biological Chemistry, vol. 288, no. 24, pp. 17202-17213.
  • Broer, S 2013, 'Diseases associated with general amino acid transporters of the solute carrier 6 family (slc6)', Current Molecular Pharmacology, vol. 6, no. 2, pp. 74-87.
  • Tumer, E, Broer, A, Balkrishna, S et al 2013, 'Enterocyte-specific Regulation of the Apical Nutrient Transporter SLC6A19 (B(0)AT1) by Transcriptional and Epigenetic Networks', Journal of Biological Chemistry, vol. 288, no. 47, pp. 33813-33823.
  • Broer, S 2013, 'Epithelial neutral amino acid transporters: lessons from mouse models', Current Opinion in Nephrology and Hypertension, vol. 22, no. 5, pp. 539-544.
  • Alexander, S, Benson, H, Faccenda, E et al 2013, 'THE CONCISE GUIDE TO PHARMACOLOGY 2013/14: OVERVIEW', British Journal of Pharmacology, vol. 170, no. 8, pp. 1449-1458.
  • Alexander, S, Benson, H et al 2013, 'SLC6 neurotransmitter transporter family', British Journal of Pharmacology, vol. 170, pp. 1728-1731.
  • S. L. Neville, J. Sjöhamn, J. A. Watts, H. MacDermott-Opeskin, S. J. Fairweather, K. Ganio, A. C. Hulyer, A. J. Hayes, A. P. McGrath, T. .R. Malcolm, M. R. Davies, N. Nomura, I. So, M. L. O'Mara, C. A. McDevitt and M. J. Maher 2021, 'The structure of the ABC transporter PsaBC shows that bacterial manganese import is achieved by unique architectural features that are conserved across the kingdoms of life', Acta Crystallographica Section A: Foundations and Advances 77(a2):C100-C100.
  • Broer, S & Gether, U 2012, 'The solute carrier 6 family of transporters', British Journal of Pharmacology, vol. 167, no. 2, pp. 256-278.
  • Rae, C, Fekete, A, Kashem, M et al 2012, 'Metabolism, Compartmentation, Transport and Production of Acetate in the Cortical Brain Tissue Slice', Neurochemical Research, vol. 37, no. 11, pp. 2541-2553.
  • Moschen, I, Broer, A, Galic, S et al 2012, 'Significance of short chain fatty acid transport by members of the monocarboxylate transporter family (MCT)', Neurochemical Research, vol. 37, no. 11, pp. 2562-2568.
  • Fairweather, S, Broer, A, O'Mara, M et al 2012, 'Intestinal peptidases form functional complexes with the neutral amino acid transporter B0AT1', Biochemical Journal, vol. 446, no. 1, pp. 135-148.
  • Bogatikov, E, Munoz, C, Pakladok, T et al 2012, 'Up-regulation of amino acid transporter SLC6A19 activity and surface protein abundance by PKB/Akt and PIKfyve', Cellular Physiology and Biochemistry, vol. 30, no. 6, pp. 1538-1546.
  • Broer, S 2011, 'Targeting tumour cells at the entrance', Biochemical Journal, vol. 439, no. 2, pp. e1-2.
  • Bailey, C, Ryan, R, Thoeng, A et al 2011, 'Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria', Journal of Clinical Investigation, vol. 121, no. 1, pp. 446-453.
  • Oppedisano, F, Pochini, L, Broer, S et al 2011, 'The B°AT1 amino acid transporter from rat kidney reconstituted in liposomes: Kinetics and inactivation by methylmercury', Biochimica et Biophysica Acta: Biomembranes, vol. 1808, no. 10, pp. 2551-2558.
  • Broer, S & Palacin, M 2011, 'The role of amino acid transporters in inherited and acquired diseases', Biochemical Journal, vol. 436, no. 2, pp. 193-211.
  • Broer, A, Juelich, T, Vanslambrouck, J et al 2011, 'Impaired Nutrient Signaling and Body Weight Control in a Na+ Neutral Amino Acid Cotransporter (Slc6a19)-deficient Mouse', Journal of Biological Chemistry, vol. 286, no. 30, pp. 26638-26651.
  • Bhavsar, S, Hosseinzadeh, Z, Merches, K et al 2011, 'Stimulation of the amino acid transporter SLC6A19 by JAK2', Biochemical and Biophysical Research Communications, vol. 414, no. 3, pp. 456-461.
  • Broer, A., Juelich, T., Vanslambrouck, J. M., Tietze, N., Solomon, P. S., Holst, J., Bailey, C. G., Rasko, J. E., Broer, S. Impaired Nutrient Signaling and Body Weight Control in a Na+ Neutral Amino Acid Cotransporter (Slc6a19)-deficient Mouse. Journal of Biological Chemistry, 286, 26638-26651
  • Yabas, M., Teh, C. E., Frankenreiter, S., Lal, D., Roots, C. M., Whittle, B., Andrews, D. T., Zhang, Y., Teoh, N. C., Sprent, J., Tze, L. E., Kucharska, E. M., Kofler, J., Farell, G. C., Bröer, S., Goodnow, C. C. & Enders, A. 2011. ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes. Nature Immunology, 12, 441-449.
  • Broer, S & Chesney, R 2010, 'Iminoglycinuria', in Valle, Beaudet, Bogelstein, Kinzler,Antonarakis and Ballabio (ed.), Scriver's Online Metabolic and Molecular Bases of Inherited Disease, McGraw-Hill Inc, New York, pp. 1-25pp.
  • O'Mara, ML, Oakley, A & Broer, S 2006, 'Mechanism and Putative Structure of B0-like Neutral Amino Acid Transporters', Journal of Membrane Biology, vol. 213, pp. 111-118.
  • Vanslambrouck, J, Broer, A, Thavyogarajah, T et al 2010, 'Renal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria', Biochemical Journal, vol. 428, pp. 397-407.
  • Balkrishna, S, Broer, A, Kingsland, A et al 2010, 'Rapid downregulation of the rat glutamine transporter SNAT3 by a caveolin-dependent trafficking mechanism in Xenopus laevis oocytes', American Journal of Physiology - Cell Physiology, vol. 299, no. 5, pp. C1047-C1057.
  • Broer, S 2010, 'Xenopus laevis Oocytes', in Qing Yan (ed.), Membrane Transporters in Drug Discovery and Development; methods and protocols (2nd ed), Humana Press Inc., New York City, pp. 295-310.
  • Broer, S 2009, 'Inherited disorders of neutral amino acid transport', Journal of Physiological Sciences, vol. 59, p. 8.
  • Broer, S 2009, 'Iminoglycinuria', in Florian Lang (ed.), Encyclopedia of Molecular Mechanisms of Disease, Springer, Berlin, pp. 1033-1034pp.
  • Broer, S 2009, 'The Role of the Neutral Amino acid Transporter B0AT1 (SLC6A19) in Hartnup Disorder and Protein Nutrition', IUBMB Life, vol. 61, no. 6, pp. 591-599.
  • Rae, C, Nasrallah, F & Broer, S 2009, 'Metabolic Effects of Blocking Lactate Transport in Brain Cortical Tissue Slices Using an Inhibitor Specific to MCT1 and MCT2', Neurochemical Research, vol. 34, pp. 1783-1791.
  • Broer, S 2009, 'Dicarboxylic Aminoaciduria', in Florian Lang (ed.), Encyclopedia of Molecular Mechanisms of Disease, Springer, Berlin, pp. 530-532pp.
  • Martin, R, Marchetti, R, Cowan, A et al. 2009, 'Chloroquine Transport via the Malaria Parasite's Chloroquine Resistance Transporter', Science, vol. 325, pp. 1680-1682.
  • Broer, S, Broer, A & Balkrishna, S 2009, 'Regulation of the rat glutamine transporter SNAT3 (Poster)', Journal of Physiological Sciences, vol. 59, pp. 493-493.
  • Broer, S, Schneider, H, Broer, A et al 2009, 'Mutation of Asparagine 76 in the Center of Glutamine Transporter SNAT3 Modulates Substrate-induced Conductances and Na+ Binding', Journal of Biological Chemistry, vol. 284, no. 38, pp. 25823-25831.
  • Broer, A, Balkrishna, S, Kottra, G et al 2009, 'Sodium translocation by the iminoglycinuria associated imino transporter (SLC6A20)', Molecular Membrane Biology, vol. 26, no. 5-7, pp. 333-346.
  • Kirk, K, Howitt, S, Broer, S et al 2009, 'Purine uptake in Plasmodium: transport versus metabolism', Trends in Parasitology, 25, 246-249.
  • Broer, S, Bailey, C, Kowalczuk, S et al 2008, 'Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters', Journal of Clinical Investigation, vol. 118, no. 12, pp. 3881-3892.
  • Broer, S 2008, 'Amino acid transport across mammalian renal and intestinal epithelia', Physiological Reviews, vol. 88, no. 1, pp. 249-286.
  • Anas, M, Lee, M, Zhou, C et al 2008, 'SIT1 is a betaine/proline transporter that is activated in mouse eggs after fertilization and functions until the 2-cell stage', Development, vol. 135, pp. 4123-4130.
  • Broer, S 2008, 'Apical Transporters for Neutral Amino acids: Physiology and Pathophysiology', Physiology, vol. 23, pp. 95-103.
  • Kowalczuk, S, Broer, A, Tietze, N et al 2008, 'A protein complex in the brush-border membrane explains a Hartnup disorder allele', FASEB Journal, vol. 22, pp. 2880-2887.
  • Azmanov, D, Kowalczuk, S, Rodgers, H et al 2008, 'Further Evidence for Allelic Heterogeneity in Hartnup Disorder', Human Mutation, vol. 29, no. 10, pp. 1217-1221.
  • Downie, M, Saliba, K, Broer, S et al 2008, 'Purine nucleobase transport in the intraerythrocytic malaria parasite', International Journal for Parasitology, 38, 203-209.
  • Broer, S 2007, 'Lysinuric protein intolerance: one gene - many problems', American Journal of Physiology - Cell Physiology, vol. 293, pp. C540-C541.
  • Broer, S, Broer, A, Hansen, J et al 2007, 'Alanine metabolism, transport, and cycling in the brain', Journal of Neurochemistry, vol. 102, no. 6, pp. 1758-1770.
  • Broer, S 2007, 'SLC38 Family of Transporters for Neutral Amino Acids', in Abel Lajtha (ed.), Handbook of Neurochemistry and Molecular Neurobiology (3rd ed), Springer, New York USA, pp. 327-338pp.
  • Lee, A, Rayfield, A, Hryciw, D et al 2007, 'Na+-H+ Exchanger Regulatory Factor 1 is a PDZ Scaffold for the Astroglial Glutamate Transporter GLAST', Glia, vol. 55, no. 2, pp. 119-129.
  • Schneider, H, Broer, S, Broer, A et al 2007, 'Heterologous Expression of the Glutamine Transporter SNAT3 in Xenopus Oocytes Is Associated with Four Modes of Uncoupled Transport', Journal of Biological Chemistry, vol. 282, no. 6, pp. 3788-3798.
  • Azmanov, D, Rodgers, H, Auray-Blais, C et al 2007, 'Persistence of the Common Hartnup disease D173N Allele in populations of European origin', Annals of Human Genetics, vol. 71, pp. 1-11.
  • Sharma, S, Dimasi, D, Broer, S et al 2007, 'Heme carrier protein 1 (HCP1) expression and functional analysis in the retina and retinal pigment epithelium', Experimental Cell Research, vol. 313, pp. 1251-1259.
  • Chubb, S, Kingsland, A, Broer, A et al 2006, 'Mutation of the 4F2 heavy-chain carboxy terminus causes y+LAT2 light-chain dysfunction', Molecular Membrane Biology, vol. 23, no. 3, pp. 255/267.
  • Broer, S 2006, 'The SLC6 orphans are forming a family of amino acid transporters', Neurochemistry International, vol. 48, pp. 559-567.
  • O'Mara, M, Oakley, A & Broer, S 2006, 'Mechanism and putative structure of B0-like neutral amino acid transporters', Journal of Membrane Biology, vol. 213, no. 2, pp. 111-118.
  • Broer, A, Tietze, N, Kowalczuk, S et al. 2006, 'The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2)', Biochemical Journal, vol. 393, pp. 421-430.
  • Broer, A, Cavanaugh, J, Rasko, J et al 2006, 'The molecular basis of neutral aminoacidurias', Pflugers Archives European Journal of Physiology, vol. 451, no. 4, pp. 511-517.
  • Downie, M, Saliba, K, Howitt, S et al 2006, 'Transport of nucleosides across the Plasmodium falciparum parasite plasma membrane has characteristics of PfENT1', Molecular Microbiology, 60, 738-748.
  • Saliba, K (co-first author), Martin, R (co-first author), Broer, A et al 2006, 'Sodium-dependent uptake of inorganic phosphate by the intracelluar malaria parasite', Nature, vol. 443, pp. 582-585.
  • Broer, S, Cavanaugh, J & Rasko, J 2005, 'Neutral amino acid transport in epithelial cells and its malfunction in Hartnup disorder', Biochemical Society Transactions, vol. 33, no. 1, pp. 233-236.
  • Bohmer, C, Broer, A, Kingsland, M et al. 2005, 'Characterization of mouse amino acid transporter Boat1(slc6a19)', Biochemical Journal, vol. 389, pp. 745-751.
  • Pauleit, D, Stoffels, G, Schaden, W et al 2005, 'PET with o-(2-18F-Fluoroethyl)-L-Tyrosine in Peripheral Tumors: First Clinical Results', Journal of Nuclear Medicine, vol. 46, no. 3, pp. 411-16.
  • Broer, S 2005, 'Lactate transportation is required for lymphoctye activation', Nature Chemical Biology, vol. 1, no. 7, pp. 356-357.
  • Kowalczuk, S, Broer, A, Kingsland, M et al. 2005, 'Molecular cloning of the mouse IMINO system: an Na+- and CI--dependent proline transporter', Biochemical Journal, vol. 386, pp. 417-422.
  • Langen, K, Hamacher, K, Bauer, D et al 2005, 'Preferred stereoselective transport of the D-isomer of cis-4-(18F)fluoro-proline at the blood-brain barrier', Journal of Cerebral Blood Flow and Metabolism, vol. 25, no. 5, pp. 607-616.
  • Bauer, D, Hamacher, K, Broer, S et al 2005, 'Preferred stereoselective brain uptake of D-serine-a modulator of glutamatergic neurotransmission', Nuclear Medicine and Biology, vol. 32, no. 8, pp. 793-797.
  • Kirk, K, Martin, R, Broer, S et al 2005, 'Plasmodium permeomics: membrane transport proteins in the malaria parasite.', Current Topics in Microbiology and Immunology, vol. 295, pp. 325-56.
  • Broer, S 2005, 'Molecular Mechanisms of Glutamate and Gklutamine Transport in Astrocytes', in Miichael Aschner (ed.), The role of Glia in Neurotoxicity, CRC Press LLC, USA, pp. 93-109.
  • Becker, H, Broer, S & Deitmer, J 2004, 'Facilitated Lactate Transport by MCT1 when Coexpressed with the Sodium Bicarbonate Cotransporter (NBC) in Xenopus Oocytes', Biophysical Journal, vol. 86, pp. 235-247.
  • Langen, K & Broer, S 2004, 'Molecular Transport Mechanisms of Radiolabeled Amino Acids for PET and SPECT', Journal of Nuclear Medicine, vol. 45, no. 9, pp. 1435-1436.
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