E&E Seminar: How to build an epigenetic time-machine: century-old chromatin architecture sequestered in museums

E&E Seminar: How to build an epigenetic time-machine: century-old chromatin architecture sequestered in museums

Co-ordinated regulation of chromatin architecture is a major driver of phenotypic diversity, development and disease but we know shockingly little about the evolutionary dynamics of chromatin reorganisation as it has occurred through time.

schedule Date & time
Date/time
5 Oct 2023 1:00pm
person Speaker

Speakers

Clare Holleley, CSIRO
next_week Event series
contact_support Contact

Description

Co-ordinated regulation of chromatin architecture is a major driver of phenotypic diversity, development and disease but we know shockingly little about the evolutionary dynamics of chromatin reorganisation as it has occurred through time. Linking the disparate fields of chromatin biology and museum science by their common use of the preservative formaldehyde, we characterise the first genome-wide historical chromatin profiles in formalin-fixed museum specimens up to 117 years old. Over-fixation modulates but does not eliminate genome-wide patterns of differential chromatin accessibility and enables semi-quantitative estimates of relative gene expression. Our methodological and analytical advances open the door to the first detailed and comprehensive view of the epigenetic past and reveal a new role for museum collections in understanding chromatin architecture dynamics over the last century.

Location

Please note: this seminar will be held in the Eucalyptus Rm and via Zoom, details are included below.

Eucalyptus Room, Rm S205, Level 2, RN Robertson Building (46)

Please click the link below to join the webinar:
https://anu.zoom.us/j/87959026320?pwd=NS9DZ1QrZXNDU0IvdWtEbTJST1FOQT09
Passcode: 452256

Canberra time: please check your local time & date if you are watching from elsewhere.

Upcoming events in this series

Darren Wong
31 Jul 2025 | 1 - 2pm

Many flowering plants have evolved diverse strategies to communicate with and attract animal pollinators. We have discovered exciting new evidence for the role of anthocyanins and terpenes in the evolution of the highly diverse terrestrial orchid subtribe Caladeniinae (Diurideae).

View the event
Emily Stringer & Jarrod Sopniewski, UC
7 Aug 2025 | 1 - 2pm

This seminar is presented by Dr Emily Stringer and Dr Jarrod Sopniewski, Postdoctoral Research Fellows from the Centre for Conservation Ecology and Genomics at the University of Canberra.

View the event
Distinguished Prof Natalia Dudareva, Purdue University
11 Aug 2025 | 1 - 2pm

Plants synthesize an amazing diversity of volatile organic compounds (VOCs) that facilitate interactions with their environment, ranging from attracting pollinators and seed dispersers to protecting themselves from pathogens, parasites, and herbivores.

View the event