Amphibians in Australia and globally face severe threats by the devastating fungal disease chytridiomycosis. Since this disease cannot be eradicated in the wild, solutions are needed that allow amphibians to survive in its presence. The genomics revolution provides an excellent opportunity to exploit these rapidly developing new tools and resources to increase amphibian disease resilience. My research focuses on using genomic tools to uncover the genetic basis of chytrid resistance and how this insight can be applied through targeted genetic intervention to boost amphibian resilience against the disease. I will also address key considerations and precautions when using genetic intervention for conservation.