Saliba Lab - Physiology and biochemistry of the malaria parasite

Malaria parasites in a red blood cell

The Saliba Lab is investigating vitamin utilisation pathways, but also pH regulation, in the red blood cell stage of the human malaria parasite Plasmodium falciparum. We are investigating these pathways/processes as potential drug targets for new antimalarials.

Members

Leader

Kevin Saliba

Kevin Saliba
Kevin Saliba obtained a BSc (Chemistry) and a PhD (Pharmacology) from the University of Cape Town, South Africa. He was a post-...

Masters Student

Occupational Trainee

PhD Student

Postdoctoral Scientist

Special Project Student

Visiting Fellow

Publications

Selected publications

  • van Schalkwyk, D.A., Chan X.W.A., Misiano, P., Gagliardi, S., Farina, C. and Saliba, K.J. (2010) Inhibition of the Plasmodium falciparum V-type H+-ATPase by small molecule indole derivatives results in rapid parasite death. Biochemical Pharmacology 79:1291-1299
  • Spry, C. and Saliba, K.J. (2009) The human malaria parasite Plasmodium falciparum is not dependent on host coenzyme A biosynthesis.  Journal of Biological Chemistry 284:24904-24913.
  • Lehane, A.M., Marchetti, R.V., Spry, C., van Schalkwyk, D.A., Teng, R., Kirk K. and Saliba, K.J. (2007) Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite.  Journal of Biological Chemistry 282:25395-25405
  • Saliba, K.J., Martin, R.E., Bröer, A., Henry, R.I., McCarthy, C.S., Downie, M.J., Allen, R.J.W., Mullin, K.A., McFadden, G.I., Bröer, S. and Kirk, K. (2006) Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite. Nature 433:582-585
  • Saliba, K.J., Allen, R.J.W., Zissis, S., Bray, P.G., Ward, S.A. and Kirk, K. (2003) Acidification of the malaria parasite’s digestive vacuole by a H+–ATPase and a H+–pyrophosphatase. Journal of Biological Chemistry 278:5605–5612
  • Saliba, K.J. and Kirk, K. (2001) H+–coupled pantothenate transport in the intracellular malaria parasite. Journal of Biological Chemistry 276:18115–18121
  • Reed, M.B., Saliba, K.J., Caruana, S.R., Kirk, K. and Cowman, A.F. (2000) Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 403:906–909
  • Saliba, K.J. and Kirk, K. (1999) pH regulation in the intracellular malaria parasite, Plasmodium falciparum: H+ extrusion via a V–type H+–ATPase. Journal of Biological Chemistry 274:33213–33219
  • Saliba, K.J., Horner, H.A. and Kirk, K. (1998) Transport and metabolism of the essential vitamin pantothenic acid in human erythrocytes infected with the malaria parasite Plasmodium falciparum. Journal of Biological Chemistry 273:10190–10195
  • Saliba, K.J., Folb, P.I. and Smith, P.J. (1998) Role for the Plasmodium falciparum digestive vacuole in chloroquine resistance. Biochemical Pharmacology 56:313–320.

News & events

News

'Concepts in Parasitology' student
18
Dec
2014
The future of parasite research in Australia will be in safe hands as 16 young Australian scientists converged for an intensive 2-week workshop with world-leading biologists to study worms, protozoans, ticks, fleas, lice and more.
Anopheles gambiae mosquitos feeding. Image credit: Johns Hopkins Malaria Research Institute
23
Jul
2013
The malaria parasite's requirement for thiamine (vitamin B1) can be targeted for the development of novel antimalarial drugs.
ARC logo
23
Nov
2010
ARC Future Fellowships Dr Lucas A Cernusak (Plant Sciences)

Highlights

Kevin Saliba

Kevin Saliba

Investigating vitamin utilisation and pH regulation pathways in the red blood cell stage of the human malaria parasite as potential drug targets for new antimalarials.

Updated:  22 July 2017/Responsible Officer:  Director RSB/Page Contact:  Webmaster RSB