Kevin Saliba

Profile

Biography

Kevin Saliba obtained a BSc (Chemistry) and a PhD (Pharmacology) from the University of Cape Town, South Africa. He was a post-doctoral fellow in the laboratory of Professor Kiaran Kirk at The Australian National University between 1997 and 2004. Late in 2004 he took up a lectureship at The Australian National University Medical School. He was promoted to senior lecturer in 2008 and Associate Professor in 2014

Research

Research interests

  • Medical Parasitology
  • Clinical Pharmacology And Therapeutics
  • Receptors And Membrane Biology
  • Cell Metabolism
  • Infectious Agents
  • Basic Pharmacology
  • Enzymes

Collaborators

  • Professor Matthias Mack (Mannheim University of Applied Sciences, Mannheim, Germany)
  • Professor Rudi Marquez (Xi'an Jiaotong - Liverpool University, China)
  • Professor Erick Strauss (Stellenbosch University, Stellenbosch, South Africa)
  • Professor Karine Auclair (McGill University, Canada)

Teaching

  • Physiology and Pharmacology to Year 1 and Year 2 MBBS students (Lecturer)
  • MBBS Research Projects (Supervisor)
  • PhB Advanced Study Courses (Supervisor).

Publications

Selected publications

  • van Schalkwyk, D.A., Chan X.W.A., Misiano, P., Gagliardi, S., Farina, C. and Saliba, K.J. (2010) Inhibition of the Plasmodium falciparum V-type H+-ATPase by small molecule indole derivatives results in rapid parasite death. Biochemical Pharmacology 79:1291-1299
  • Spry, C. and Saliba, K.J. (2009) The human malaria parasite Plasmodium falciparum is not dependent on host coenzyme A biosynthesis.  Journal of Biological Chemistry 284:24904-24913.
  • Lehane, A.M., Marchetti, R.V., Spry, C., van Schalkwyk, D.A., Teng, R., Kirk K. and Saliba, K.J. (2007) Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite.  Journal of Biological Chemistry 282:25395-25405
  • Saliba, K.J., Martin, R.E., Bröer, A., Henry, R.I., McCarthy, C.S., Downie, M.J., Allen, R.J.W., Mullin, K.A., McFadden, G.I., Bröer, S. and Kirk, K. (2006) Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite. Nature 433:582-585
  • Saliba, K.J., Allen, R.J.W., Zissis, S., Bray, P.G., Ward, S.A. and Kirk, K. (2003) Acidification of the malaria parasite’s digestive vacuole by a H+–ATPase and a H+–pyrophosphatase. Journal of Biological Chemistry 278:5605–5612
  • Saliba, K.J. and Kirk, K. (2001) H+–coupled pantothenate transport in the intracellular malaria parasite. Journal of Biological Chemistry 276:18115–18121
  • Reed, M.B., Saliba, K.J., Caruana, S.R., Kirk, K. and Cowman, A.F. (2000) Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature 403:906–909
  • Saliba, K.J. and Kirk, K. (1999) pH regulation in the intracellular malaria parasite, Plasmodium falciparum: H+ extrusion via a V–type H+–ATPase. Journal of Biological Chemistry 274:33213–33219
  • Saliba, K.J., Horner, H.A. and Kirk, K. (1998) Transport and metabolism of the essential vitamin pantothenic acid in human erythrocytes infected with the malaria parasite Plasmodium falciparum. Journal of Biological Chemistry 273:10190–10195
  • Saliba, K.J., Folb, P.I. and Smith, P.J. (1998) Role for the Plasmodium falciparum digestive vacuole in chloroquine resistance. Biochemical Pharmacology 56:313–320.

All publications

Updated:  21 November 2017/Responsible Officer:  Director RSB/Page Contact:  Webmaster RSB