Broer Lab - Membrane transport and nutrition

Broer lab

Nutrients are essential for the growth and maintenance of cells and organisms. Membrane transporters are essential to deliver nutrients to cells and tissues and thus play a significant role in the regulation of metabolism. We study the role of amino acid transport in the onset of insulin resistance and the regulation of carbohydrate metabolism. Amino acid transport is crucial for growing cells and thus is a target to curtail cancer growth. We are investigating in how far amino acid transport in cancer cells is different from normal cells. In addition to amino acid transport we investigate the role of phospholipid transport in cell development and signalling in the immune system.

Members

Leader

Stefan Broer

Stefan Broer
Stefan studied Biochemistry at the University of Tuebingen/Germany from 1981 to 1986. He completed his Masters in 1987 and...

Projects

Open to students

Publications

Selected publications

  • Bröer A, Rahimi F, Bröer S. Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells. J Biol Chem. 2016 Apr 26.
  • Jiang Y, Rose AJ, Sijmonsma TP, Bröer A, Pfenninger A, Herzig S, Schmoll D, Bröer S. Mice lacking neutral amino acid transporter B(0)AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control. Mol Metab. 2015; 4(5):406-17.
  • Tumer, E., Broer, A., Balkrishna, S., Julich, T. and Broer, S. (2013) Enterocyte-specific regulation of the apical nutrient transporter SLC6A19 (B(0)AT1) by transcriptional and epigenetic networks. The Journal of biological chemistry. 288, 33813-33823
  • Yabas, M., Teh, C. E., Frankenreiter, S., Lal, D., Roots, C. M., Whittle, B., Andrews, D. T., Zhang, Y., Teoh, N. C., Sprent, J., Tze, L. E., Kucharska, E. M., Kofler, J., Farell, G. C., Broer, S., Goodnow, C. C. and Enders, A. (2011) ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes. Nat Immunol. 12, 441-449
  • Broer, S. and Palacin, M. (2011) The role of amino acid transporters in inherited and acquired diseases. Biochem J. 436, 193-211
  • Kowalczuk, S., Broer, A., Tietze, N., Vanslambrouck, J. M., Rasko, J. E. and Broer, S. (2008) A protein complex in the brush-border membrane explains a Hartnup disorder allele. Faseb J. 22, 2880-2887
  • Seow, H. F., Broer, S., Broer, A., Bailey, C. G., Potter, S. J., Cavanaugh, J. A. and Rasko, J. E. (2004) Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19. Nat Genet. 36, 1003-1007
  • Broer, A., Klingel, K., Kowalczuk, S., Rasko, J. E., Cavanaugh, J. and Broer, S. (2004) Molecular Cloning of Mouse Amino Acid Transport System B0, a Neutral Amino Acid Transporter Related to Hartnup Disorder. J Biol Chem. 279, 24467-24476.

All publications

News & events

News

06
Sep
2016
Did you miss the inaugural RSB public forum? Click here to listen
09
May
2016
RSB researchers have found a vital supply route that cancer cells use to obtain their nutrients, in a discovery that could lead to new treatments to stop the growth of tumours.
17
Nov
2015
Professor Stefan Broer has been awarded a Diabetes Australia grant to study the targeting of amino acid transport to treat type 2 diabetes.  The award was announced by the Federal Health Minister,
Image: Sohal Parvez Haque, Flickr.
15
May
2015
Australian researchers have discovered a link between protein intake and improved control of blood glucose in mice, opening the way for potential new treatments for type 2 diabetes in humans.

Pages

Highlights

Breaking the PhD mould: finding a career outside academia

Like many PhD students, Sarojini always imagined she would continue in research before she decided to pursue a career within the pharmaceutical industry. Sarojini’s passion for research flourished while studying at the ANU Research School of Biology.

How a rare disorder can lead to possible treatments for type 2 diabetes

Hartnup disorder is a rare disorder that is caused by an inability to absorb the breakdown products of protein digestion, namely amino acids. The disorder is named after the first reported case that showed symptoms similar to pellagra, a vitamin deficiency.

New treatments for T2 diabetes and cancer

If you think transporters are just for Star Trek fans, think again.  Professor Stefan Broer is using the transporters in cell membranes to develop new treatments for Type 2 diabetes and cancer.

The degree so good, you’ll never want it to end

Most students are happy to lay down their pens after submitting their honours thesis. But not Tze How Goh. The Bachelor of Science (Advanced) honours student has just finished his thesis, but is already back in the lab, continuing his research into treatments for diabetes.

Updated:  27 April 2017/Responsible Officer:  Director RSB/Page Contact:  Webmaster RSB