The impact of DNA sequence variants on epigenetic processes and their capacity to respond to contrasting environmental inputs

In recent times, sequencing data in several organisms revealed a high level of inter-individual variability at the levels of genotypes, gene expression and DNA methylation suggesting that epigenomic dynamics may be generated by a poorly understood interplay of these three levels of genome activity. The aim of this project is to understand how DNA polymorphism generates sequence variability that may lead to differential methylation of genes whose expression is regulated in a context-dependent manner.