The Rug Lab - Malaria host/pathogen relationships

The lab’s research revolves mainly around questions in malaria host/pathogen relationships. Genetic engineering (fluorescence tagging of proteins of interest or generating deletion mutants) allows us to identify various aspects in parasite-induced trafficking pathways in the human red blood cell and how the parasite establishes itself for survival in its host environment by applying various biochemical and advanced microscopy techniques. Our imaging expertise spans from fluorescence microscopy via scanning and transmission electron microscopy to elaborate combinations of these techniques, giving us insight into the ‘inner world’ of the parasite’s function. We recently have also integrated 3D imaging like micro-computed tomography to study biology and function within varies other parasite species.

Profile of Dr Melanie Rug.

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