Hardham Group - Plant pathogen interactions

Phytophthora spore with adhesive secretions. SEM by Roger Heady and Adrienne Hardham

The group investigates the cellular and molecular basis of the infection of plants by Phytophthora and fungal pathogens, employing a fully integrated approach that uses the latest techniques in molecular genetics, genomics, cell biology and microscopy.

Adrienne Hardham is not taking new group members.



Selected publications

  • Zhang, W., Blackman, L.B. and Hardham, A.R.  (2013) Transient fusion and selective secretion of vesicle proteins Phytophthora nicotianae zoospores.  PeerJ. 1, e221
  • Hardham, A.R. (2013) Microtubules and biotic stress.  Plant Journal.  75: 278-289.
  • Ve, T., Williams, S., Catanzariti, A.-M., Rafiqi, M., Rahman, M., Ellis, J.E., Hardham, A.R., Jones, D.A., Anderson, P.A., Dodds, P.N. and Kobe, B.  (2013) Structures of the flax-rust effector AvrM reveal insights into the molecular basis of host-cell entry and effector-triggered immunity.  PNAS 110,17594-17599.
  • Hee, W.Y., Torreña, P.S., Blackman, L.M. and Hardham, A.R. (2013)  Phytophthora cinnamomi in Australia.  In:Phytophthora A Global Perspective.  Ed: K. Lamour. Pp. 124-134.
  • Ludowici, V., Zhang, W., Blackman, L.M. and Hardham, A.R. (2013)  Phytophthora nicotianae.  In: PhytophthoraA Global Perspective.  Ed: K. Lamour. Pp. 113-123.
  • Gan, P. H. P., Dodds, P.N. and Hardham, A.R.  (2012) Plant infection by biotrophic fungal and oomycete pathogens.  In: Signalling and Communication in Plant Symbiosis.  Eds: S. Perotto and F. Baluska.  Springer-Verlag, Berlin. Pp. 183-212.
  • Hardham, A.R. (2012) Confocal microscopy in plant-pathogen interactions.  In: Plant Fungal pathogens: Methods and Protocols.  Eds: M.D. Bolton and B.P.H.J. Thomma. Humana Press, New York.  295-309.
  • Takemoto, D., Rafiqi, M., Hurley, U., Lawrence, G.J., Bernoux, M., Hardham, A.R., Ellis, J.G., Dodds, P.N. and Jones, D.A. (2012) N-terminal motifs in some plant disease resistance proteins function in membrane attachment and contribute to disease resistance.  Molecular Plant-Microbe Interacteractions  25, 379-392.
  • Rafiqi, M., Ellis, J.G., Ludowici, V.A., Hardham, A.R. and Dodds, P.M.  (2012) Challenges and progress towards understanding the role of effectors in plant–fungal interactions.  Current Opinion in Plant Biology 15, 1-6.
  • Zhang, M., Meng, Y., Wang, Q., Liu, D., Quan, J., Hardham, A.R. and Shan, W. (2012) PnPMA1, an atypical plasma membrane H+-ATPase, is required for zoospore development in Phytophthora parasitica.  Fungal Biology 116: 1013-1023.
  • Blackman, L.M., Arikawa, M., Yamada, S., Suzaki, T. and Hardham, A.R.  (2011)  Identification of a mastigoneme protein from Phytophthora nicotianae.  Protist 162, 100-114.
  • Koeck, M., Hardham, A.R. and Dodds, P.N. (2011) The role of effectors of biotrophic and hemibiotrophic fungi in infection.  Cellular Microbiology 13, 1849-1857.
  • Rafiqi, M., Gan, P.H.P., Ravensdale, M., Lawrence, G.J., Ellis, J.G., Jones, D.A., Hardham, A.R. and Dodds, P.N. (2010) Internalization of flax rust avirulence proteins into plant cells occurs in the absence of the pathogen.  Plant Cell 22, 2017-2032.
  • Narayan, R.D., Blackman, L.M., Shan, W. and Hardham, A.R. (2010) Phytophthora nicotianae transformants lacking dynein light chain 1 produce non-flagellate zoospores.  Fungal Genetics and Biology 47, 663-671.
  • Gan, P.H.P., Rafiqi, M., Ellis, J.G., Jones, D.A., Hardham, A.R. and Dodds, P.N. (2010) Lipid binding activities of flax rust AvrM and AvrL567 effectors. Plant Signalling and Behaviour 5, 1-4.
  • Gan, P.H.P., Rafiqi, M., Hardham, A.R. and Dodds, P.N. (2010) Effectors of biotrophic fungal plant pathogens.Functional Plant Biology 37, 913-918.
  • Hardham, A.R. and Cahill, D.M. (2010) Oomycete effectors.  Functional Plant Biology 37, 919-925.
  • Hardham, A.R., Takemoto, D. and White, R.G. (2008) Rapid and dynamic subcellular reorganization following mechanical stimulation of Arabidopsis epidermal cells mimics responses to fungal and oomycete attack. BMC Plant Biology 8, 63-77.
  • Blackman L.M. and Hardham, A.R. (2008) Regulation of catalase activity and gene expression during Phytophthora nicotianae development and infection of tobacco.  Molecular Plant Pathology 9, 495-510.
  • Hardham, A.R. (2007) Cell biology of plant-oomycete interactions.  Cellular Microbiology 9, 31-39.
  • Hardham, A.R., Takemoto, D. and Jones, D.A. (2007) Cytoskeleton and cell wall function in penetration resistance.  Current Opinion in Plant Biology 10, 342-348.
  • Hardham, A.R. (2005) Pathogen Profile: Phytophthora cinnamomi.  Molecular Plant Pathology 6, 589-604.

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Staff of RSB have been awarded eleven ARC Discovery Grants, two LIEF (Linkage Infrastructure, Equipment and Facilities) grants and four DECRA (Discovery Early Career Researcher Award) Fellowships.


Azolla root structure

Azolla is a genus of aquatic ferns that are highly productive and can grow at great speeds in the summer months. Azolla species are useful for studying the mechanics of cell division and differentiation in the roots due to their simple structure and determinate growth.

Updated:  21 October 2019/Responsible Officer:  Director RSB/Page Contact:  Webmaster RSB