Broer Group - Membrane transport and nutrition

Nutrients are essential for the growth and maintenance of cells and organisms. Membrane transporters are essential to deliver nutrients to cells and tissues and thus play a significant role in the regulation of metabolism. We study the role of amino acid transport in the onset of insulin resistance and the regulation of carbohydrate metabolism. Amino acid transport is crucial for growing cells and thus is a target to curtail cancer growth. We are investigating in how far amino acid transport in cancer cells is different from normal cells. In addition to amino acid transport we investigate the role of phospholipid transport in cell development and signalling in the immune system.

Members

Leader

Stefan Broer

Stefan Broer
Stefan studied Biochemistry at the University of Tuebingen/Germany from 1981 to 1986. He completed his Masters in 1987 and...

Projects

Open to students

Publications

Selected publications

  • Bröer A, Rahimi F, Bröer S. Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells. J Biol Chem. 2016 Apr 26.
  • Jiang Y, Rose AJ, Sijmonsma TP, Bröer A, Pfenninger A, Herzig S, Schmoll D, Bröer S. Mice lacking neutral amino acid transporter B(0)AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control. Mol Metab. 2015; 4(5):406-17.
  • Tumer, E., Broer, A., Balkrishna, S., Julich, T. and Broer, S. (2013) Enterocyte-specific regulation of the apical nutrient transporter SLC6A19 (B(0)AT1) by transcriptional and epigenetic networks. The Journal of biological chemistry. 288, 33813-33823
  • Yabas, M., Teh, C. E., Frankenreiter, S., Lal, D., Roots, C. M., Whittle, B., Andrews, D. T., Zhang, Y., Teoh, N. C., Sprent, J., Tze, L. E., Kucharska, E. M., Kofler, J., Farell, G. C., Broer, S., Goodnow, C. C. and Enders, A. (2011) ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes. Nat Immunol. 12, 441-449
  • Broer, S. and Palacin, M. (2011) The role of amino acid transporters in inherited and acquired diseases. Biochem J. 436, 193-211
  • Kowalczuk, S., Broer, A., Tietze, N., Vanslambrouck, J. M., Rasko, J. E. and Broer, S. (2008) A protein complex in the brush-border membrane explains a Hartnup disorder allele. Faseb J. 22, 2880-2887
  • Seow, H. F., Broer, S., Broer, A., Bailey, C. G., Potter, S. J., Cavanaugh, J. A. and Rasko, J. E. (2004) Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19. Nat Genet. 36, 1003-1007
  • Broer, A., Klingel, K., Kowalczuk, S., Rasko, J. E., Cavanaugh, J. and Broer, S. (2004) Molecular Cloning of Mouse Amino Acid Transport System B0, a Neutral Amino Acid Transporter Related to Hartnup Disorder. J Biol Chem. 279, 24467-24476.

All publications

News & events

News

Rice, carbohydrate
29
Apr
2013
Stefan Broer, a Professor in the Research School of Biology, was interviewed by the Canberra Ti
Steaks grilling
16
Jun
2011
Adjusting the intake of high protein foods like meat, eggs and milk products could determine whether you become a rugby player or marathon runner and may help you lose weight, according to new research published this month in the Journal of Biological Chemistry.
ARC logo
23
Nov
2010
ARC Future Fellowships Dr Lucas A Cernusak (Plant Sciences)
Hydroxyproline
06
Nov
2008
To find a cure for cancer, haemophilia and other diseases, researchers need to be looking for complex, interacting genetic factors, according to the authors of a new study.

Pages

Highlights

Breaking the PhD mould: finding a career outside academia

Like many PhD students, Sarojini always imagined she would continue in research before she decided to pursue a career within the pharmaceutical industry. Sarojini’s passion for research flourished while studying at the ANU Research School of Biology.

How a rare disorder can lead to possible treatments for type 2 diabetes

Hartnup disorder is a rare disorder that is caused by an inability to absorb the breakdown products of protein digestion, namely amino acids. The disorder is named after the first reported case that showed symptoms similar to pellagra, a deficiency of the vitamin Niacin.

New treatments for T2 diabetes and cancer

If you think transporters are just for Star Trek fans, think again.  Professor Stefan Broer is using the transporters in cell membranes to develop new treatments for Type 2 diabetes and cancer.

The degree so good, you’ll never want it to end

Most students are happy to lay down their pens after submitting their honours thesis. But not Tze How Goh. The Bachelor of Science (Advanced) honours student has just finished his thesis, but is already back in the lab, continuing his research into treatments for diabetes.

Updated:  21 April 2019/Responsible Officer:  Director RSB/Page Contact:  Webmaster RSB