Jennifer Graves

Jennifer Graves
Ecology and Evolution
Emeritus Professor
R N Robertson Building
 03 9439 5109

Profile

Career awards

Biography

Jenny is a Professor Emeritus at ANU. She no longer leads a lab at this University. She has returned to Melbourne, where her primary position is:

Distinguished Professor Jenny Marshall Graves AO, FAA
La Trobe Institute of Molecular Science
La Trobe University
Melbourne, VIC 3086

Research

Research interests

Jenny's research focusses on the understanding of mammalian genome organization and evolution, exploiting the genetic diversity of Australia's unique mammals as a source of genetic variation to study highly conserved genetic structures and processes. This strategy is used to shed light on the organization, function and evolution of mammalian genomes, leading to new theories of the origin and evolution of human sex chromosomes and sex determining genes. Early work made classic contributions to our understanding of the molecular mechanism of X chromosome inactivation and the control of DNA synthesis in mammalian cells.

Teaching

Jenny is an occasional guest speaker. She no longer takes students.

Publications

Selected publications

  • Graves, J.A.M. 2014. The epigenetic sole of sex and dosage compensation. Nature Genetics 46, 215–217 
  • Ezaz,  T., Azad, B., O’Meally, D., Young, M.J., Matsubara, K., Edwards, M.J., Zhang, X., Holleley, C.E., Deakin, J.E., Graves, J.A.M., Georges, A., Edwards, S.V. and Sarre, S.D. 2013. Sequence and gene content of a large fragment of a lizard sex chromosome and evaluation of candidate sex differentiating gene R-spondin 1. BMC Genomics 17;14:899.
  • Deakin, J.E., Delbridge, M.L., Koina, E., Harley, N., Alsop, A.E., Wang, C., Patel, V.S and Graves, J.A.M. 2013. Reconstruction of the ancestral marsupial karyotype from comparative gene maps. BMC Evol Biol. 13: 258.
  • Nishimoto, M., Katano, M., Yamagishi, T., Hishida, T., Kamon, M., Nabeshima, Y., Katsura, Y., Satt, Y., Deakin, J.E., Graves, J.A.M., Kuroki, Y., Ono, R., Ishino, F., Kato, H., Okuda, A. 2013. In vivo function and evolution of the eutherian-specific pluriopotency marker UTF1. PLoS One 8: e68119.  doi:10.1371
  • Graves, J.A.M. and Renfree, M.B. 2013. Marsupials in the age of genomics. Ann Rev. Genomics and Human Genetics 14: 13.1–13.28
  • Graves, J.A.M. 2013. Kangaroo gene mapping and sequencing; insights into mammalian genome evolution. Aust. J. Zoology 61: 4-12
  •  Livernois, A.M., Al Nadaf, S., Deakin, J.E., Graves, J.A.M., Waters, P.D.  2013. Independent evolution of transcriptional inactivation on sex chromosomes in birds and mammals. PLoS Genetics 9: e1003635. doi:10.1371
  • Tsukamato, K., Deakin, J.E.., Graves, J.A.M. and Hashimoto, K. 2013. Exceptionally high conservation of the MHC Class-I-related gene, MR1, among mammals. Immunogenetics  65:115-24.
  • Graves, J.A.M. 2013. How to evolve new vertebrate sex determining genes. Developmental Dynamics 242: 354-359
  • Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. Bender HS, Murchison EP, Pickett HA, Deakin JE, Strong MA, Conlan C, McMillan DA, Neumann AA, Greider CW, Hannon GJ, Reddel RR, Graves JAM PLoS One. 2012;7(9):e46195. doi: 10.1371/journal.pone.0046195. Free PMC Article
  • Genomic restructuring in the Tasmanian devil facial tumour: chromosome painting and gene mapping provide clues to evolution of a transmissible tumour.
  • Deakin JE, Bender HS, Pearse AM, Rens W, O'Brien PC, Ferguson-Smith MA, Cheng Y, Morris K, Taylor R, Stuart A, Belov K, Amemiya CT, Murchison EP, Papenfuss AT, Graves JA.PloS G enet. 2012;8(2):e1002483. doi: 10.1371/journal.pgen.1002483. 
  • Evolutionary history of novel genes on the tammar wallaby Y chromosome: Implications for sex chromosome evolution.
  • Murtagh VJ, O'Meally D, Sankovic N, Delbridge ML, Kuroki Y, Boore JL, Toyoda A, Jordan KS, Pask AJ, Renfree MB, Fujiyama A, Graves JA, Waters PD. Genome Res. 2012 Mar;22(3):498-507. doi: 10.1101/gr.120790.111. 
  • Are some chromosomes particularly good at sex? Insights from amniotes. O'Meally D, Ezaz T, Georges A, Sarre SD, Graves JA. Chromosome Res. 2012 Jan;20(1):7-19. doi: 10.1007/s10577-011-9266-8. 
  • The origin and evolution of vertebrate sex chromosomes and dosage compensation. Livernois AM, Graves JA, Waters PD. Heredity (Edinb). 2012 Jan;108(1):50-8. doi: 10.1038/hdy.2011.106. Epub 2011 Nov 16.
  • A cross-species comparison of escape from X inactivation in Eutheria: implications for evolution of X chromosome inactivation. Al Nadaf S, Deakin JE, Gilbert C, Robinson TJ, Graves JA, Waters PD. Chromosoma. 2012 Feb;121(1):71-8. doi: 10.1007/s00412-011-0343-8. 
  • Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic. Al Nadaf S, Waters PD, Koina E, Deakin JE, Jordan KS, Graves JA. Genome Biol. 2010;11(12):R122. doi: 10.1186/gb-2010-11-12-r122. 
  • Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development. Renfree MB, Papenfuss AT, Deakin JE, Lindsay J, Heider T, Belov K, Rens W, Waters PD, Pharo EA, Shaw G, Wong ES, Lefèvre CM, Nicholas KR, Kuroki Y, Wakefield MJ, Zenger KR, Wang C, Ferguson-Smith M, Nicholas FW, Hickford D, Yu H, Short KR, Siddle HV, Frankenberg SR, Chew KY, Menzies BR, Stringer JM, Suzuki S, Hore TA, Delbridge ML, Patel HR, Mohammadi A, Schneider NY, Hu Y, O'Hara W, Al Nadaf S, Wu C, Feng ZP, Cocks BG, Wang J, Flicek P, Searle SM, Fairley S, Beal K, Herrero J, Carone DM, Suzuki Y, Sugano S, Toyoda A, Sakaki Y, Kondo S, Nishida Y, Tatsumoto S, Mandiou I, Hsu A, McColl KA, Lansdell B, Weinstock G, Kuczek E, McGrath A, Wilson P, Men A, Hazar-Rethinam M, Hall A, Davis J, Wood D, Williams S, Sundaravadanam Y, Muzny DM, Jhangiani SN, Lewis LR, Morgan MB, Okwuonu GO, Ruiz SJ, Santibanez J, Nazareth L, Cree A, Fowler G, Kovar CL, Dinh HH, Joshi V, Jing C, Lara F, Thornton R, Chen L, Deng J, Liu Y, Shen JY, Song XZ, Edson J, Troon C, Thomas D, Stephens A, Yapa L, Levchenko T, Gibbs RA, Cooper DW, Speed TP, Fujiyama A, Graves JA, O'Neill RJ, Pask AJ, Forrest SM, Worley KC. Genome Biol. 2011 Aug 29;12(8):R81. doi: 10.1186/gb-2011-12-8-r81. Erratum in: Genome Biol. 2011;12(12):414. Patel, Hardip R. 

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