Illa Tea

Rm E205, Level 2, RN Robertson Building (46)
 +61 2 6125 0381 (Office)


Research interests

  • Isotopic composition of mammalians (13C, 15N, 34S)
  • Metabolomics & fluxomics in mammalian
  • Cancer metabolism
  • isotope effect and mammalian metabolism


Lecturer in BIOL3110/6100- Isotopes in Biogeochemistry environment authentication


49. P B-K. Kouamé, D. Toure, L. Kablan, G. Bedi, I. Tea, R. Robins, J C. Chalchat, F. Tonzibo, Chemical Constituents and Antibacterial Activity of Essential Oils from Flowers and Stems of Ageratum conyzoides from Ivory Coast Records of Natural Products 2017 

48. I. Tea & G. Tcherkez, Natural Isotope Abundance in Metabolites: Techniques  and kinetic isotope effect measurement in plant, animal, and human tissues Methods in Enzymology 596 (2017),113-147

47. I. Tea, E. Martineau, I. Antheaume, J. Lalande, C. Mauve, F. Gilard, S. Barillé-Nion, A. C. Blackburn, G. Tcherkez 13C and 15N natural isotope abundance reflects breast cancer cell metabolism Scientific Reports 6 (2016): 34251

46. C. Mauve, N. Giraud, E.R.A. Boex-Fontvieille, I. Antheaume, I. Tea, G. Tcherkez, Kinetic commitment in the catalysis of glutamine synthesis by GS1 from Arabidopsis using 14N/15N and solvent isotope effects Plant Physiology and Biochemistry 108 (2016) 203e211

45. G. Cantalapiedra-Hijar, I. Ortigues-Marty, A.M. Schiphorst, R.J. Robins, I. Tea, S. Prache, Natural 15N abundance in key amino acids from lamb muscle: exploring a new horizon in diet authentication and assessment of feed efficiency in ruminants Journal of Agricultural and Food Chemistry 64 (2016), 4058-67

44. MD. Dioum, M. Seck, V. Silvestre, D. Loquet, S. Lohard, S. Barille-Nion, GS Remaud, RJ Robins, I Tea, A Ring-D-Seco-Tetranortriterpenoid from Seeds of Carapa procera Active against Breast Cancer Cell Lines Planta Medica 82 (2016), 967-72

43. M. Jégou, F. Gondret, J. Lalande‑Martin, I. Tea, E. Baéza, I. Louveau. NMRbased metabolomics highlights differences in plasma metabolites in pigs exhibiting dietinduced differences in adiposity Eur J Nutr 55 (2016), 1189-99

42. J-N. Dumez, J. Milani, B. Vuichoud, A. Bornet, J. Lalande-Martin, I. Tea, M. Yon, M. Maucourt, C. Deborde, A. Moing, L. Frydmane, G. Bodenhausen, S. Jannin, P. Giraudeau, Hyperpolarized NMR of plant and cancer cell extracts at natural abundance Analyst 140 (2015), 5860-63

41. DG. Diomande, E. Martineau, A. Gilbert, P. Nun, A. Murata, K. Yamada, N. Watanabe, I. Tea, RJ. Robins, N. Yoshida, GS. Remaud. Position-specific isotope analysis of xanthines: a 13C nuclear magnetic resonance method to determine the 13C intramolecular composition at natural abundance Analytical chemistry 87 (2015), 6600-6

40. D. Diomande, I. Antheaume, M. Leroux, J. Lalande, S. Balayssac, GS. Remaud, I. Tea. Multi-element, multi-compound isotope profiling as a means to distinguish the geographical and varietal origin of fermented cocoa (Theobroma cacao L.) beans Food Chem 188 (2015), 576-582

39. E. Baéza, M. Jégou, F. Gondret, J. Lalande-Martin, I. Tea, E. Le Bihan-Duval, C. Berri, A. Collin, S. Métayer-Coustard, I. Louveau, S. Lagarrigue, M. J. Duclos. Pertinent plasma indicators of the ability of chickens to synthesize and store lipids Anim. Sci. 93 (2015), 107–116

38. A. De Luca, S. Laugier, I. Tea, RJ. Robins, P-J. Saulnier, F. Torremocha, X. Piguel, R. Marechaud, R. Hankard, S. Hadjadj. Impact on bulk 15N natural isotopic abundance in hair of kidney function in type 2 diabetic nephropathy E-SPEN journal 9 (2015), e204-e209

37. M. Yon, J. Lalande, T. Harris, I. Tea, P. Giraudeau, L. Frydman. 13C NMR detection of metabolic mixtures enhanced by Dynamic Nuclear Polarization ScienceJet 4 (2015), 82

36. P. Giraudeau, I. Tea, GS. Remaud, S. Akoka. Reference and normalization methods: essential tools for the intercomparison of NMR spectra – A review J Pharm Biomed Anal. 93 (2014), 3-16

35. K. M. Romek, M. Julien, M. Frasquet-Darrieux, I.Tea, I. Antheaume, R. Hankard, RJ. Robins. Human baby hair amino acid natural abundance N-15- isotope values are not related to the N-15-isotope values of amino acids in mother's breast milk protein Amino Acids 45 (2013), 1365-1372

34. U. Bussy, P. Giraudeau, I. Tea, M. Boujtita. Understanding the degradation of electrochemically-generated reactive drug metabolites by quantitative NMR Talanta 116 (2013), 554-558

33. U. Bussy, M. Delaforge, C. El-Bekkali, V. Ferchaud-Roucher, M. Krempf, I. Tea, N. Galland, D. Jacquemin, M. Boujtita. Acebutolol and Alprenolol metabolism predictions: comparative study of electrochemical and cytochrome P450 catalyzed reactions using liquid chromatography coupled to high resolution mass spectrometry Anal Bioanal Chem. 405 (2013), 6077-85

32. F. Courant, A. Martzolff, G. Rabin, J-P. Antignac, B. Le Bizec, P. Giraudeau, I. Tea, S. Akoka, A. Couzinet, G. Cogne, D. Grizeau, O. Gonçalves. How metabolomics can contribute to bio-processes: a proof of concept study for biomarkers discovery in the context of nitrogen-starved microalgae grown in Photobioreactors Metabolomics. 9 (2013), 1286-1300

31. G. Tcherkez, I. Tea. 32S/34S isotope fractionation in plant sulphur metabolism - A review New Phytol. 200 (2013), 44-53

30. U. Bussy, P. Giraudeau, V. Silvestre, T.jaunet-lahary, V. Ferchaud-Roucher, M. Krempf, S. Akoka, I. Tea, M. Boujtita. In situ NMR spectroelectrochemistry for the structure elucidation of unstable intermediate metabolites Anal Bioanal Chem. 405 (2013), 5817-5824

29. I. Tea, A. Le Guennec, M. Frasquet-Darrieux, M. Julien, I Antheaume, R. Hankard, R. Robins. Simultaneous determination of natural-abundance d15N values and quantity of individual amino acids in proteins from milk of lactating women and from infant hair using an isotope ratio mass spectrometry Rapid Commun. Mass Spectrom. 27 (2013), 1345-1353

28. MC. Alexandre-Gouabau, F. Courant, T. Moyon, A. Küster, G. Le Gall, I. Tea, J-P. Antignac, D. Darmaun. Maternal and cord blood LC-HRMS metabolomics reveal alterations in energy and polyamine metabolism, and oxidative stress in very-low-birth-weight infants J Proteom Res.12 (2013), 2764-78

27. P B-K. Kouamé, V. Silvestre, G. Bedi, D. Loquet, RJ. Robins, I. Tea.  Phytochemical investigation of the leaves of Leptoderris fasciculata  Phytochem Letters. 6 (2013), 253–256

26. M. Pathan, B. Charrier, I. Tea, S. Akoka, P. Giraudeau. New practical tools for the implementation and use of ultrafast 2D NMR experiments Magn. Reson. Chem. 51 (2013), 168–175

25. U. Bussy, I. Tea, V. Ferchaud-Roucher, M. Krempf, V. Silvestre, N. Galland, D. Jacquemin, M. Andresen Bergström, U. Jurva, M. Boujtita. Mass Voltammetry Technique in the Presence of Isotopic 18O Labeled Water for the prediction of oxidative metabolism Anal. Chem. Acta. 762 (2013), 39–46

24. P B-K. Kouamé, C. Jacques, G. Bedi, V. Silvestre, D. Loquet, S. Barillé-Nion, RJ. Robins, I. Tea.  Phytochemicals Isolated from Leaves of Chromolaena odorata: Impact on Viability and Clonogenicity of Cancer-Cell Lines Phytotherapy Res. 27 (2013), 835-840

23. A. Le Guennec, I. Tea, I. Antheaume, E. Martineau, B. Charrier, M. Pathan, S. Akoka, P. Giraudeau. Fast determination of absolute metabolite concentrations by spatially-encoded 2D NMR: application to breast cancer cell extracts Anal. Chem. 84 (2012), 10831–10837

22. E. Martineau, I. Tea, S. Akoka, P. Giraudeau. Absolute quantification of metabolites in breast cancer cell extracts by quantitative 2D 1H INADEQUATE NMR NMR in Biomed 25 (2012), 985–992

21. U. Bussy, V. Ferchaud-Roucher, I. Tea, M. Krempf, V. Silvestre, M. Boujtita. Electrochemical oxidation behavior of Acebutolol and identification of intermediate species by liquid chromatography and mass spectroscopy Electrochemica Acta. 69 (2012), 351–357

20. A. de Luca, N. Boisseau, I. Tea, I. Louvet, RJ. Robins, A. Fohran, M-A. Charles, R. Hankard. 15N content in newborns' hair and their mothers: a cohort study Pediatric Res. 71 (2012), 598–604

19. I. Tea, I Antheaume, B-L. Zhang. Tracing the origin of cyanide by isotope ratio mass spectrometry for forensic investigation Forensic. Sci. Int. 217 (2012), 168–173

18. I. Tea, G. Le Gall, A. Küster, N. Guignard, M-C. Alexandre-Gouabau, D. Darmaun, R. Robins. 1H-NMR based metabolic profiling of maternal and umbilical cord blood indicates altered maternal-fœtal nutrient exchange in preterm infants Plos One. 7 (2012), e29947

17. A. Küster, I. Tea, V. Ferchaud-Roucher, S. Le Borgne, C. Plouzennec, N. Winer, J-C. Rozé, RJ. Robins, D. Darmaun. Cord blood glutathione depletion in preterm infants: role of maternal cysteine supply Plos One. 6 (2011), e27626

16. E. Martineau, I. Tea, G. Loaëc, P. Giraudeau, S. Akoka. Strategy for choosing extraction procedures for NMR-based metabolomic analysis of mammalian cell Anal. Bioanal. Chem. 401 (2011), 2133–42

15. I. Tea, K. Kosieradzka, I Antheaume, E. Gentil, RJ. Robins. Determination of the concentration of nitrogenous bio-organic compounds using an isotope ratio Mass Spectrometer operating in continuous flow mode Anal. Bioanal. Chem. 401 (2011), 1263-71

14. M. Pathan, S. Akoka, I. Tea, B. Charrier, P. Giraudeau. Multi-scan single shot quantitative 2D NMR: a valuable alternative to fast conventional quantitative 2D NMR Analyst. 136 (2011), 3157-63

13. E. Martineau, P. Giraudeau, I. Tea, S. Akoka. Fast and precise quantitative analysis of metabolic mixtures by 2D 1H INADEQUATE NMR J. Pharm. Biomed. Anal.  54 (2011), 252-257

12. I. Tea, I Antheaume, J. Besnard, RJ. Robins. Determination of the natural abundance d15N of taurine by Gas Chromatography-isotope ratio measurement by Mass Spectrometry Rapid. Commun. Mass Spectrom. 24 (2010), 1-7

11. K. Kosieradzka, I. Tea, E. Gentil, RJ. Robins. Determination of the natural abundance delta N-15 of nortropane alkaloids by gas chromatography-isotope ratio mass spectrometry of their ethylcarbamate esters Anal. Bioanal. Chem. 396 (2010), 1405-1414

10. Küster, I. Tea, S. Sweeten, RJ. Robins, Dominique Darmaun. Simultaneous determination of glutathione and cysteine concentrations and 2H enrichments in microvolumes of neonatal blood using gas chromatography-mass spectrometry Anal. Bioanal. Chem. 390 (2008), 1403-12

9. I. Tea, V. Ferchaud-Roucher, A. Küster, D. Darmaun, RJ. Robins. Determination of 13C isotopic enrichment of glutathione and glycine by gas chromatography /combustion/ isotope ratio mass spectrometry after formation of the N- or N,S-ethoxycarbonyl methyl ester derivatives Rapid Commun. Mass Spectrom. 21 (2007), 3245-52

8. I. Tea, T. Genter, N. Naulet, M. Lummerzheim, D. Kleiber. Interaction between nitrogen and sulfur by foliar application and its effects on flour bread-making quality J. Sci. Food Agric. 87 (2007), 2853-2859

7. O. Surel, O. Darde, I. Tea, F. Violleau, D. kleiber. Behaviour of wheat protein during dough mixing: comparison of three mixers Sciences des Aliments. 26 (2006), 247-258

6. K. Oikonomopoulou, KK. Hansen, M. Saifeddine, I. Tea, M. Blaber, SI. Blaber, I. Scarisbrick, P. Andrade-Gordon, GS. Cottrell, NW. Bunnett, EP. Diamandis, MD. Hollenberg. Proteinase-activated receptors (PARs): targets for kallikrein signalling J. Biol. Chem. 281 (2006), 32095-3211

5. K. Oikonomopoulou, KK. Hansen, M. Saifeddine, N. Vergnolle, I. Tea, M. Blaber, SI. Blaber, I. Scarisbrick, EP. Diamandis, MD. Hollenberg. Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs) Biol. Chem. 387 (2006), 817-24

4. K. Oikonomopoulou, KK. Hansen, M. Saifeddine, N. Vergnolle, I. Tea, EP. Diamondis, MD. Hollenberg. Proteinase mediated cell signalling: Targeting Proteinase-Activated Receptors (PARs) by kallikreins and more Review. Biol. Chem. 387 (2006), 677-85

3. I. Tea, T. Genter, D. Kleiber. Changes in the glutathione thiol-disulfide status in wheat grain by foliar fertilization: Consequences for the Rheological Properties of Dough J. Cereal Sci. 41(2005), 305-315

2. I. Tea, T. Genter, N. Naulet, V. Boyer, D. Kleiber. Effect of nitrogen and sulphur foliar fertilization on wheat storage protein composition and dough mixing properties Cereal Chem. 81 (2004), 759-766

1. I. Tea, T. Genter, N. Naulet, E. Morvan, D. Kleiber. Isotopic study of post-anthesis foliar incorporation of sulphur and nitrogen in wheat Isotopes Environ. Health Stud. 39 (2003), 289-300

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