Joe completed his Bachelor of Philosophy (a research-focussed science degree) at the Australian National University, for which he received First Class Honours and the University Medal in Chemistry (2014). His Honours research in Colin Jackson’s group (2014) involved investigating the emergence and evolution of new enzyme function from non-catalytic ancestral proteins. Prior to this, Joe undertook research on the interaction of antimalarial compounds with the Plasmodium falciparum chloroquine resistance transporter (Kirk & Martin Groups, 2013), the dynamics of voltage gated sodium channels (Corry Group, 2013), and the characterisation of triazine degrading enzymes (Jackson Group, 2013).
Joe returned to ANU in 2016 to begin a PhD in the Jackson group, where he is studying the evolution of new enzyme function, the structure and function of bicarbonate binding proteins (with the Price Group, RSB), and antibody-antigen interactions involved with antimalarial vaccinations (with the Cockburn Group, JCSMR).
LinkedIn Profile: https://www.linkedin.com/in/joe-kaczmarski-ab621a114/
- Kaczmarski, J, Mahawaththage Don, M, Feintuch, A et al. 2020, 'Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme', Nature Communications, vol. 11, no. 1.
- Kaczmarski, J, Hong, N, Mukherjee, B et al. 2019, 'Structural Basis for the Allosteric Regulation of the SbtA Bicarbonate Transporter by the P-II-like Protein, SbtB, from Cyanobium sp. PCC7001', Biochemistry, vol. 58, no. 50, pp. 5030-5039.
- Kaczmarski, J, Mitchell, J, Spence, M et al 2019, 'Structural and evolutionary approaches to the design and optimization of fluorescence-based small molecule biosensors', Current Opinion in Structural Biology, vol. 57, pp. 31-38.
- Greule, A, Izoré, T, Iftime, D et al 2019, 'Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics', Nature Communications, vol. 10.
- Izoré, T, Tailhades, J, Hansen, M et al 2019, 'Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain', PNAS - Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 8, pp. 2913-2918.
- Clifton, B, Kaczmarski, J, Carr, P et al 2018, 'Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein', Nature Chemical Biology, vol. 14, no. 6, pp. 542-547pp.
- Fisher, C, Sutton, H, Kaczmarski, J et al 2017, 'T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein', PLoS Pathogens, vol. 13, no. 7, pp. 23pp.
- Kaczmarski, J & Corry, B 2014, 'Investigating the size and dynamics of voltage-gated sodium channel fenestrations A molecular dynamics study', Channels, vol. 8, no. 3, pp. 264-277.