Associate Professor Rick Pearson, Division of Cancer Research, Peter MacCallum Cancer Centre.
Sir Peter MacCallum, Department of Oncology, University of Melbourne, Melbourne, Australia.
The dysregulation of ribosome biogenesis invariably occurs in cancer cells. However, a critical, unresolved question has been whether the accelerated ribosome is required for malignancy. Here we show that the PI3K/AKT pathway, deregulated in a high proportion of human tumours, is a critical regulator of ribosome biogenesis.