Functional interaction between carbonic anhydrases and acid/base-coupled membrane transporters.

Date & time

1pm 7 March 2012

Location

Slatyer Seminar Room, RN Robertson Building (46), ANU

Description

Professor Joachim W. Deitmer

Several acid/base-coupled membrane transporters, pH-regulating as well as metabolite carriers, such as sodium/bicarbonate cotransporter (NBC) and monocarboxylate transporters (MCTs),
are modulated by carbonic anhydrases (CA). The mechanism of this interaction may be quite variable, being either dependent on, or independent of, the catalytic activity of CAs. In this seminar both mechanisms and the interaction specificity between different isoforms of carriers and CAs are discussed.

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