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The Australian National University

Broer Lab - Epithelial transporters

Teaching | Research | Research opportunities | Lab members | Lab awards | Publications | Grants

Professor Stefan Broer

Building 134,
Research School of Biology,
The Australian National University,
Acton, ACT 0200
T: 61252540
E: stefan.broer@anu.edu.au

 Biography:

Stefan studied Biochemistry at the University of Tuebingen/Germany from 1981 to 1986. He completed his Masters in 1987 and moved to the Research Center in Juelich where he worked on amino acid producing bacteria during his PhD. He was awarded his PhD in 1991 and moved to the University of Illinois in Chicago as a research fellow of the German Science Foundation. In 1993 he was appointed as Junior Lecturer at the University of Tuebingen in the Institute of Physiological Chemistry. In 1998 Stefan was promoted to Senior Lecturer and moved to the Institute of Physiology at the University of Tuebingen. In 2000 Stefan moved to the ANU as a Senior Lecturer in the School of Biochemistry and Molecular Biology. He was promoted to Associate Professor in 2006 and to full Professor in 2008. Stefan was treasurer and council member of the Australian Physiological Society from 2005-2009.

Teaching

Research interests

Membrane transporters in health and disease

Student research opportunities

Diseases of amino acid transport

Disorders of epithelial transport affecting intestinal and renal transport        Show more detail...

The role of amino acids in diabetes

Amino acid are important nutrients that regulate metabolism.        Show more detail...

Cancer metabolism

Cancer cells use amino acid to generate energy. We are investigating amino acid transport and metabolism in cancer cells.        Show more detail...

The role of phospholipid flippases in the immune system

B-cell development requires a specific distribution of membrane phospholipids. Mutations in enzymes mediating phospholipid transport can cause immunodeficiency.        Show more detail...

Lab members

  • Stefan Broer (Lab Leader)
  • Angelika Broer (Research Officer)
  • Qi Cheng (PhD student)
  • Stephen Fairweather (PhD student)
  • Erandi Hewawasam (Honours Student)
  • Yang Jiang (PhD student)
  • Emrah Tumer (PhD student)
  • Mehmet Yabas (Research Officer)

» Go to lab directory

Lab awards and achievements

Awards to members of the lab

Sarojini Balkrishna (2009) Travel grant,  Congress of the International Union of Physiological
Sciences in Kyoto, Japan.
Sarojini Balkrishna (2008) Combio - ASBMB Student Poster Prize
Angelika Broer (2009) Vice chancellor's award for career achievment

Publications

Selected publications

1 Tumer, E., Broer, A., Balkrishna, S., Julich, T. and Broer, S. (2013) Enterocyte-specific regulation of the apical nutrient transporter SLC6A19 (B(0)AT1) by transcriptional and epigenetic networks. The Journal of biological chemistry. 288, 33813-33823
2 Yabas, M., Teh, C. E., Frankenreiter, S., Lal, D., Roots, C. M., Whittle, B., Andrews, D. T., Zhang, Y., Teoh, N. C., Sprent, J., Tze, L. E., Kucharska, E. M., Kofler, J., Farell, G. C., Broer, S., Goodnow, C. C. and Enders, A. (2011) ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes. Nat Immunol. 12, 441-449
3 Broer, S. and Palacin, M. (2011) The role of amino acid transporters in inherited and acquired diseases. Biochem J. 436, 193-211
4 Broer, A., Juelich, T., Vanslambrouck, J. M., Tietze, N., Solomon, P. S., Holst, J., Bailey, C. G., Rasko, J. E. and Broer, S. (2011) Impaired Nutrient Signaling and Body Weight Control in a Na+ Neutral Amino Acid Cotransporter (Slc6a19)-deficient Mouse. J Biol Chem. 286, 26638-26651
5 Bailey, C. G., Ryan, R. M., Thoeng, A. D., Ng, C., King, K., Vanslambrouck, J. M., Auray-Blais, C., Vandenberg, R. J., Broer, S. and Rasko, J. E. (2011) Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria. J Clin Invest. 121, 446-453
6 Kowalczuk, S., Broer, A., Tietze, N., Vanslambrouck, J. M., Rasko, J. E. and Broer, S. (2008) A protein complex in the brush-border membrane explains a Hartnup disorder allele. Faseb J. 22, 2880-2887
7 Seow, H. F., Broer, S., Broer, A., Bailey, C. G., Potter, S. J., Cavanaugh, J. A. and Rasko, J. E. (2004) Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19. Nat Genet. 36, 1003-1007
8 Broer, A., Klingel, K., Kowalczuk, S., Rasko, J. E., Cavanaugh, J. and Broer, S. (2004) Molecular Cloning of Mouse Amino Acid Transport System B0, a Neutral Amino Acid Transporter Related to Hartnup Disorder. J Biol Chem. 279, 24467-24476

All publications

Click here to see a full list of publications on the ISI website...

Recent grants


1. Broer, S. and A. Enders. (2014) AUD 440,172, 3 years, Phospholipid dependent signaling in B-cells, NHMRC, Project Grant GNT1061288
2. Broer, S. (2013) AUD 637,131, 3 years, SLC6A19 - Human target validation and assay generation, Sanofi-Aventis, Sponsored research
3. Broer, S. (2012) AUD 50,540, 2 years, The role of amino acids in insulin resistance, Sanofi-Aventis, Sponsored research
4. Broer, S. (2011) AUD 120,000, Real time monitor for cell growth and motility, Australian National University, Major Equipment Grant 11MEC23
5. Broer, S., et al. (2010) AUD 379,125, 3 Years, The role of the glutamine transporter SNAT3 in ion transport, cell signaling and ammonia detoxification, NHMRC, Project Grant 585479
6. Broer, S. (2009) AUD 284250, 3 Years, Metabolic complexes of the brush-border membrane, NHMRC, Project Grant 284250




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