pH regulation in the malaria parasite

Plasmodium proton pump

Description

The malaria parasite expresses at least two types of protons pumps. One of these, the V-type ATPase, has been shown to be essential for the parasite’s ability to regulate its cytosolic and digestive vacuole pH. The role played by the other proton pump, the V-type pyrophosphatases, is less clear. We are currently investigating the role played by these pumps in pH regulation within the parasite and whether they may be suitable antimalarial drug targets.

Partnerships

Work in this area is carried out in collaboration with Professor Kiaran Kirk (ANU), Professor Leann Tilley (La Trobe University), Dr Alex Maier (ANU) and Professor Akhil Vaidya (Drexel University).

Updated:  29 June 2017/Responsible Officer:  Director RSB/Page Contact:  Webmaster RSB