Cellular adaptations that allow the transmission and survival of Plasmodium falciparum when taken up by the mosquito

The environment encountered by the malaria parasite in the mosquito is very different from the surrounding in the human host (temperature, available nutrients, immune system,....). We are looking at the necessary differentiation a malaria parasite undergoes before it can be taken up from human blood by the mosquito vector. These changes are irreversible and essential for transmission. A better understanding of these processes could provide clues how to prevent the transmission of malaria and therefore deliver additional instruments in the fight against this disease.