Skip navigation

Djordjevic Lab - Plant development and stem cell biology, bioactive molecules and biofuel production

Teaching | Research | Research opportunities | Lab members | Lab awards | Publications | Grants

Assoc Prof Michael Djordjevic

Research School of Biology,
The Australian National University,
Acton, ACT 0200
T: 61253088
E: Michael.Djordjevic@anu.edu.au

 Biography:

Associate Professor Michael Djordjevic obtained a Bachelor of Science with First Class Honours from the University of Queensland in 1980 and a PhD in Molecular Biology from the ANU in 1984. He was awarded an Australian National Research Fellowship in 1984 and a Post Doctoral Fellowship from the Australian Wool Board Trust Fund in 1985. He is a Chief Investigator and Node Leader in the ARC Centre of Excellence for Integrative Legume Research (CILR).  His seminal research identified key components of the molecular dialogue between rhizobia and legumes. He was an early pioneer of the application of proteomics and mass spectrometry to address problems in biology. A long term interest is the molecular analysis of the flavonoid biosynthesis pathway and the role of flavonoids in regulating plant development. In collaboration with Professor Parish at the John Curtin Medical School of Medical Research and other CILR researchers he has identified Rhizobium-derived Nod factors, potent regulators of plant development, as modulators of mammalian angiogenesis. He has initiated research to understand the lipid biosynthesis pathway in Chlamydomonas reinhardtii and the application of this research to biofuel production. His recent interest includes identifying new molecules, especially regulatory secondary metabolites and microRNAs, that control plant development.

Teaching

BIOL 2121 Genes to Environment Lecturer

Research interests

  • The control of root architecture in legumes.
  • The identification of new angiogenesis therapeutics.
  • The use of microalgae as a renewable energy source.

Current projects

Control of Meristem Differentiation and Plant Architecture in Legumes

Plant Development is Controlled by New Regulatory Molecules        Show more detail...

Novel Small Molecule Regulators of Animal Development

Identification and characterisation of small plant-bioactive molecules that regulate mammalian development        Show more detail...

Chlamydomonas as a model system to optimise lipid production for biofuels

Optimising microalgae for biofuel production        Show more detail...

Student research opportunities

Understanding the role of key regulators in determining root architecture

Investigating the role of genes that control root architecture        Show more detail...

Lab members

  • Charles Buer (Research Fellow)
  • Christina Delay (PhD student)
  • Michael Djordjevic (Lab Leader)
  • Rod Eyles (PhD student)
  • Nijat Imin (Research Fellow)
  • Gabriel James (PhD student)
  • Farzaneh Kordbacheh (PhD student)
  • Nadiatul Akmal Mohd Radzman (PhD student)
  • Marie Oakes (Senior Technical Officer)
  • Ann Wilks (School Visitor)

» Go to lab directory

Collaborations

Lab awards and achievements

  • New components of regulatory networks that control the numbers of root nodules formed on Medicago have been identified.
  • Methodologies for isolating variant Chlamydomonas strains that accumulate high levels of neutral lipids have been devised [James et al. 2010 Fatty Acid Profiling of Chlamydomonas reinhardtii under Nitrogen Deprivation. Bioresource Technology (in press)]. 
  • Key genes involved in the induction of in vitro somatic embryogenesis and root formation in Medicago truncatula have been identified (Holmes et al. 2010. Global gene expression analysis of in vitro root formation in Medicago truncatula. Functional Plant Biology, 2010, 37, 1117–1131).
  • Flavonoids act as long-distance plnat development signals and modulators of plant architecture  (Buer et al. 2010. Flavonoids: New Roles for Old Molecules. Journal of Integrative Biology. 52: 98–111).
  •  Plant bioactive molecules (Nod factors and secondary plant metabolites) have been shown to modulate in vitro angiogenesis in rodent and human model systems in a concentration-dependent fashion.
  •  Extracellular endo- and exo-proteases have been identified that process CLE pro-peptides to biologically active peptide hormone products of different sizes and biological potency.
  • A new classificiation system for Hox proteins has been proposed  (Hueber et al. 2010. Improving Hox Protein Classification across the Major Model Organisms. PLOS ONE 5: e10820)
  • The use of microalgal biomass as a source of renewable energy is being investigated via the BioSolar Project (a cross campus collaboration between biologists and engineers).
  • As part of the BIOL2121 teaching team, Dr. Michael Djordjevic was awarded the Vice Chancellor's Excellence in Teaching Award (2010).

Publications

Selected publications

Buer, CS, Muday GK and Djordjevic, M.A. (2007). Flavonoids are differentially taken up, converted to downstream products, and transported long distances in Arabidopsis. Plant Physiology. 145 : 478-490.

Miyahara A, Hirani TA, Oakes M Kereszt A, Kobe B, Djordjevic M A., Gresshoff PM. (2008) Soybean nodule autoregulation receptor kinase phosphorylates two kinase-associated protein phosphatases in vitro. Journal of Biological Chemistry: 283: 25381-253

Djordjevic M.A., Chen H-C, Natera, SHA, van Noorden G., Menzel, C, Taylor, S., Geiger O, Weiller, G. (2003). A global analysis of protein expression profiles in Sinorhizobium meliloti: Discovery of new genes for nodule occupancy and stress adaptation. Molecular Plant-Microbe Interactions.16: 508-524.

Natera, S. H. A., Guerreiro N., Djordjevic, M. A. (2000). Proteome analysis of differentially displayed proteins as a tool for the investigation of symbiosis. Molecular Plant-Microbe Interactions, 13, 995-1009.

Mathesius U, Schlaman HRM, Spaink HP, Sautter C, Rolfe BG and Djordjevic MA (1998) Auxin transport inhibition precedes nodule initiation in white clover roots and is regulated by flavonoids and derivatives of chitin oligosaccharides. Plant Journal. 14: 23-34

Recent Publications

Djordjevic M.A., Oakes M.., Hocart C., Li, D. and Gresshoff, P.M. (2007). Analysis of secreted proteins present in Glycine max xylem sap. Journal of Proteome Research. 6: 3771-3779.

Buer CS, Djordjevic MA. (2009) Architectural phenotypes in the transparent testa mutants of Arabidopsis thaliana. J Experimental Botany 60 : 751-763.

Hueber SD, Weiller GF, Djordjevic MA, Frickey T. (2010). Improving Hox Protein Classification across the Major Model Organisms. PLOS ONE 5: e10820

Holmes P., Djordjevic M A. and Imin N (2010) Global gene expression analysis of in vitro root formation in Medicago truncatula. Functional Plant Biology. 2010, 37, 1117–1131.

James G.O., Hocart CH, Hillier W., Chen, H., Kordbacheh F., Price D and Djordjevic MA. (2010) Fatty Acid Profiling of Chlamydomonas reinhardtii under Nitrogen Deprivation. Bioresearch Biotechnology. doi: 10.1016/j.biortech.2010.11.051

All publications

Click here to see a full list of publications on the ISI website...

Recent grants

2008-2010 CEO348212 ARC Centre of Excellence for Intergative Legume Research

2009 Proof-of-concept grant ANU Connect Ventures. Synthesis of Nod factor variants that regulate mammalian angiogenesis. 

2010-12 DP1096299 Dr MA Djordjevic; Prof LN Mander; Prof CR Parish New functions for bioactive flavonoids in plants and mammals.

2010 Optimising Lipid Yields in Microalgae for Next Generation Biofuels SA-Manitoba Bilateral agreement






Back to top

Updated:  21 December 2010/Responsible Officer:  Director RSB /Page Contact:  RSB Webmaster