Research projects
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Mechanisms by which a chromatin-modifying gene targets gene expression and promotes memoryEpignetics is a memory forming process in plants that involves chromatin modifications. This proposal will unravel the regulatory mechanisms controlling carotenoid composition and epigenetic events in plants. |
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Identification of novel carotenoid-derived signalling pathways affecting plant developmentCarotenoids are colourful plant pigments. This proposal aims to identify new carotenoid signaling pathways regulating development in response to environmental change. |
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The molecular nature of metabolic feedback regulation by metabolite-binding RNA riboswitchesMetabolite binding RNA riboswitches are rare in plants. This proposal will invesigate a putative metabolite-binding riboswitch in Arabidopsis. |
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Regulation of carotenoid composition, growth habit and root-mycorrhizal symbiosis in tomatoCarotenoids play important roles in mediating root-mycorrhizal symbiosis as well as defining growth habit and development. This proposal will investigate how perturbing carotenoid compositon in tomato affects such processes. |
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Carotenoids and Plant DevelopmentThis proposal will unravel the regulatory mechanisms controlling carotenoid composition as well as plant growth. |
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Molecular virologyCharacterising the genes of the Vaccinia virus |
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Immunodominance in CD8+ T cell responses to vaccinia virusUnderstanding and manipulating CD8+ T cell responses to viruses and genetically engineered virus vaccines |
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Understanding how host genes affect anti-viral immunityA study of the outcome of vaccination or virus infection in mice with mutations that affect anti-viral responses |
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Understanding how environmental gradients impact on plant performanceA wide range of student opportunities are available in the area of environmental plant physiology/physiological ecology, including those listed under 'Current Projects'. Please email Owen.Atkin@anu.edu.au for further details. |
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Role of poisonous plants in the foraging ecology of marsupialsMost of the plants that browsing mammals eat contain a complex series of natural toxins. How do these influence the plants animals choose to eat? |
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Genetics and evolution of variation in chemical defence against herbivoresWhy are some trees defended against herbivores and others not? Even when they grow right next to each other? Is it because of variations in soils or are genetic factors more important? |
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How do animals learn about poisonous plants?Animals don't forage randomly and have to make decisions continuously about nutrients and toxins in their food. How do they make decisions when the environment is so variable and when they also have to consider predators and social interactions? |
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Viruses and immunityEnquiries from prospective students with enthusiasm for immunology or virology are welcome. |
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Asexual Sporulation in Stagonospora nodorumTo understand the molecular mechanisms of asexual sporulation in the pathogen Stagonospora nodorum |
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Genetics of thyroid diseaseInvestigating the genetics of thyroid disease in the Canberra region |
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Investigating the genetics of obesityUsing the Aussie Normal collection of genotype and phenotype information, investigating genes involved in obesity. This project is in collaboration with staff at JCSMR. |
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Investigating the genetics of cardiovascular diseaseUsing the "Aussie Normal" collection genotype and phenotype investigations of markers of cardiovascular disease. |
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Effector proteins in necrotrophic wheat pathogensEffector proteins cause disease! How do they do it? |
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Understanding the role and identifying targets of signal transduction in Stagonospora nodorumWhat are the targets of signal transduction in fungal pathogens? |
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Ion regulation in the malaria parasite |
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Drug resistance and drug susceptibility in the malaria parasite |
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Metabolism and metabolomics of the malaria parasite |
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The biochemistry, physiology and pharmacology of the malaria parasiteEnquiries from prospective students are welcome. |
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Research Projects (BIOL3174 or BIOL3175)Interested in undertaking a research project to gain experience of common methodologies used in biochemistry and molecular biology? |
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Biotechnology Research Proposal (BIOL8703)Projects covering epigenetics, miRNAs, seed development and plant development are available. |
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Summer Research Projects 2012/2013Through this project, you will gain knowledge and experience of common methodologies used in molecular biology. |
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Honours Research Project 2012 or 2013Interested in joining our lab to undertake your honours project? |
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RNA silencing and heritable epigenetic changesThe aim of this project is to investigate the extent of trans-generational effects of endogenous small RNAs in the model plant Arabidopsis. |
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What molecular components are required for cell-to-cell movement of RNA silencing?The aim of this project is to investigate the molecular components required for cell-to-cell movement of RNA silencing in the model plant Arabidopsis. |
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Does RNA silencing contribute to seed size and hybrid incompatibility?The aim of this project is to investigate the extent that seed size and endosperm development is determine by small RNAs in the model plant Arabidopsis. |
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Honours, Masters and PhD projects available in fungal phytopathologyAll current projects in the Solomon lab are available as Honours, Masters and PhD research projects |
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Assaying Zic5 function in the developing mouse brainThis project focuses specifically on a condition called microcephaly, a neuro-developmental disorder in which a forebrain of normal architecture but reduced size is generated in utero. |
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An improved Zic trans-activation assayThe aim of this project is to construct a more sensitive trans-activation assay to enable discrimination between Zic family members with respect to their ability to trans-activate the reporter. |
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A new gene involved in mammalian axis formationOne aim of the project is to identify the mutated gene responsible for axis duplication. The second aim of the project is to characterize the phenotype of embryos that are homozygous for the mutation. |
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Identification and characterisation of genes that are required for mammalian embryonic development |
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The colon environment as a determinant of E. coli diversity |
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Host social structure and the clonal composition of bacterial populations |
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Subcellular localisation of plant disease resistance proteinsWe have used green fluorescent protein fusions to localise flax resistance proteins conferring resistance to flax rust. |
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Activation of plant disease resistance proteinsWe have used site-directed mutagenesis and agroinfiltration to investigate molecular function in the tomato Cf-9 protein conferring leaf mould resistance. |
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Identification and functional characterisation of flax rust Avr genesThis project will combine next generation sequencing, bioinformatics and classical genetics to identify new Avr genes, and use an array of molecular and cell biology techniques to analyse Avr gene function. |
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Mapping and functional characterisation of the tomato I-7 gene for resistance to Fusarium wiltThis project aims to characterise I-7 resistance by microscopic analysis and digital gene expression analysis. We also aim to map I-7 and develop PCR-based markers for marker-assisted breeding of I-7. |
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Identification and functional characterisation of the tomato I-3 gene for resistance to Fusarium wilt.This project aims to identify the I-3 gene and to characterise the I-3 protein. We also aim to characterise I-3 resistance by microscopic analysis and digital gene expression analysis. |
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The Zic genes and congenital defects- |
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Multifocal visual evoked potentialsmeasuring electrical responses of the visual system to many stimuli at the same time |
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Multifocal pupillographic objective perimetrysimilar to multifocal VEPs but where visual brain responses are recorded by video records of motions of the pupils |
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Higher order image statistics and image textureWhat is image structure, how do we compute it? How does our brain use it? |
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The spatial frequency doubling illusionWhen pushed the visual system responds in an odd way creating illusory percepts of textural fineness. We want to study the neural basis of these effects. |
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Rates of molecular evolution in parasitesA broad comparative study using analysis of DNA sequence data from a wide range of parasites and their non-parasitic relatives |
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Evolution of salt tolerance in plantsA biodiversity-based approach, using analysis of large-scale molecular phylogenies to understand adaptation to challenging environments |
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Evolution of scald and net form of net blotchEvolution of cereal pathogens |
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Speciation in co-evolved taxa: sexually-deceptive orchids and their mycorrhizal symbionts.Speciation processes in mycorrhizae and orchids |
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Fungal bioinformaticsIdentifying genes associated with mycorrhizae |
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Ascochyta blight of chickpeaPopulation structure of A. rabiei |
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Environmental risk assessment of genetically modified Alfalfa mosaic virus resistant white clover (Trifolium repens L.)Risk assessment of AMV resistant clover |
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Australian native truffle diversityAustralian native truffle diversity |
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Factors affecting Perigord truffle production in AustraliaFactors affecting Perigord truffle production in Australia |
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Pest resistance and sustainable plantation management of eucalyptsInsect and vertebrate herbivores represent an important cost to eucalypt forestry. Our work aims assess the potential for breeding resistant trees in order to improve the viability of plantations especially in farm forestry. |
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Ecology, genetics and physiology of animal-plant interactionsEnquires from prospective students are welcome in any of the areas described above. |
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Nutrition of free-ranging primatesHow do primates make a living in natural forests when nutrients are either poorly available or sparsely distributed? |
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Diseases of amino acid transportDisorders of epithelial transport affecting intestinal and renal transport |
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Amino acid transporters as signalling moleculesTransporters are involved in metabolite uptake and signalling processes |
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Amino acid transporters as ion channelsTransporter and channels are related, some proteins have both functions |
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From Animal to Robots and BackWe investigate the knowledge-base of detouring and goal-directed navigation in insects |
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Visual Information Processing under Natural ConditionsCombining field work on crab behaviour with electrophysiological and optical techniques, this projects aims to understand how fiddler crabs use visual information to organise their anti-predator behaviour under natural conditions. |
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Colour Vision in Australian MarsupialsMarsupials are the only non-primate mammals with trichromatic colour vision. This project aims to understand the diversity and mechanisms of their colour vision using behavioural, anatomical and physiological techniques. |
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Alarm signals and interspecific eavesdroppingWe test ideas about the information encoded in alarm calls and used by others of the same and different species |
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Parent-offspring communication under the risk of predationWe are interested in how acoustic communication between parents and their offspring is shaped by the risk of predation |
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Vocal mimicryWe study the acoustic accuracy, context and possible functions of avian vocal mimicry |
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Acoustic communication in birdsMost of my students study acoustic communication in birds |
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Regulation of cricket salivary glandsExamines the way that feeding affects the morphology and chemistry of the insect salivary gland. |
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Feeding and ecology of grapevine scalesThe phenology and ecology of grapevine scales in the region around the ACT are being studied to understand the reason these insects are a problem to the wine industry. |
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Regulation of rat reproduction in rice fields of south east AsiaNatural chemicals are being screened to determine how rat reproduction may be controlled in the rice fields. |
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Biological adaptation under natural and anthropogenic conditionsCombining mathematical and empirical work to understand what (if anything) is optimized by evolution across various levels of biological organization. |
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From Molecules to MemoryTo understand how long-term memories are stored in the brain. Model organism: social bees. |
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Epigenetic integration of genomic and environmental information in honey beesTo study the link between DNA methylation and environmental influences. |
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How DNA-methylation contributes to long-term memoryTo examine changes in the epigenome associated with the consolidation of long-term memory |
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Eco-evolutionary feedbacksInvestigating the rules of the "evolutionary play in the ecological theatre" |
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Epigenomics of brain wiring and behaviour in honey beesTo study epigenetic profiles of neuronal cell types in the honey bee brain |
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Tracking the evolution of devil facial tumour diseaseCharacterisation of normal and tumour genomes at the cytogenetic level |
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Duetting and female song in Australian passerinesSeveral projects are available to explore the social and ecological conditions that select for song in female birds |
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Out of the darkness: predicting rates of respiration of illuminated leaves along nutrient gradientsThis project seeks to establish whether there are systematic differences in light inhibition among species, and how phosphorus limitations and diurnal variations in temperature impact on leaf respiration. |
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The evolution of mouth markings in estrildid finchesThe aim of this project is to test whether the bright mouth markings of estrildid finches have evolved to provide a means of discriminating brood parasitic chicks in the nest |
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Leaf respiration under drought: a global perspectiveWe are combining laboratory and field experiments to establish whether there are systematic differences among species in drought-mediated changes in respiration, and how drought impacts on the temperature dependence of respiration |
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Establishing a process-based understanding of the impacts of climate change on plant respirationOur aim is to establish a process-based understanding of mitochondrial and intact tissue respiratory responses to drought and global warming scenarios |
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Role of alanine aminotransferase in improved nitrogen use efficiency in cerealsThis project is defining the phenotype of transgenic crop plants that have improved nitrogen use efficiency |
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Co-evolution between Australian cuckoos and their hostsA range of projects are available to explore the tactics deployed by cuckoos to fool their hosts, and the reciprocal strategies that have evolved in hosts to defend themselves against brood parasites |
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Structural and functional analysis of glucosyl and O-acetyl transferases of Shigella flexneri |
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The role of N-terminal post-translational modifications of the tobacco Rubisco large subunitUnderstanding the role and function of post translational protein modifications in chloroplasts using the model protein Rubisco |
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Dendritic cell biologyCharacterisation of a novel antigen presenting cell |
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Environmental physiology of locustsTemperature regulation and acclimation of locusts to high and low temperatures. Reproductive physiology of locusts. |
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Studies on the biochemical regulation of C3 and C4 photosynthesis |
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CO2 diffusion inside leaves |
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Insect ecology, morphology or physiologyAny topic that encompasses some aspect of insect feeding biology or morphology will be supported. |
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Stem Cell NichesThe endothelial cell microenvironment in spleen |
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Stem Cells in Immunology |
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Extramedullary HematopoiesisSpleen as a site for myelopoiesis |
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Transcriptome and genome sequencing of the coral, Acropora millepora.Our goal is to achieve transcriptome and genome sequence databases that are as complete as possible. |
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Expression of modified tobacco and foreign Rubiscos in tobacco chloroplastsExamining how plant photosynthesis and growth is influenced by transplanting foriegn or modified Rubisco into higher plant chloroplasts |
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Diversification and macroevolution of Proteaceae. |
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Rarity and extinction risk in the southwest Australian flora. |
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Diversity and coexistence in southwest Australian plant assemblages. |
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Diversity and macroecology of island mammals. |
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Global patterns of biodiversity. |
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Organic components of the coral skeletonOrganic components of the coral skeleton We are using mass spectrometry, in conjunction with our nearly complete transcriptome, to identify organic components of the coral skeleton. |
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Comparative genomics and development of coralsHigh throughput sequencing, combined with in situ hybridization, allows us to investigate how homologous genes are expressed in animals of quite different morphologies during development. |
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Biophysical coupling in coral reef ecosystemsUnravelling how physio-chemical gradients influence coral reef ecosystem processes over space and time. |
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Adaptive swimming behaviour in coral reef fishesBehavioural flexibility as a means of adaptation to a rapidly changing environment. |
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Development of the coral nervous system and its role in metamorphosisThe availability of transcriptome data allows us to take new approaches in our studies of the structure and function of the coral nervous system. |
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The molecular basis of coral biologyEnquiries from prospective students and post-docs are welcome. |
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Student research projects in CO2 fixation and water loss of leaves |
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Microbial control of root developmental plasticityThe aim of this project is to identify mechanisms that link microbial signals with changes in root development. |
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The role of flavonoids in root-microbe symbioses and root developmentThe aim of this project is to understand the molecular mechanisms of plant flavonoids in root-bacterial and root-nematode interactions. |
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Environmental regulation of root symbiosesThe aim of this project is to find out how changes in the environment interfere with the success of nitrogen fixing symbioses. |
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Rhizosphere signallingThe aim of this project is to find out how microbial signals from the rhizosphere alter root symbioses and root development |
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The evolution of genital size in mosquitofishWhy do genitalia show such a precise allometric relationship with body size in these fish? |
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Examining Rubisco - Rubisco activase interactions.Genetic, biochemical and physiological tools are being used to explore which residues in Rubisco and its chiropractic helper protein, Rubisco activase, that influence their interactions |
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The Directed evolution of RuBisCOThe powerful protein engineering tool of laboratory evolution is being applied to Rubisco |
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Exploring the evolutionary protein landscape of RubiscoProjects are available that aim to exploit, and upgrade, our novel Rubisco evolution screening systems |
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Overcoming limitations in engineering the Rubisco small subunits in higher plant chloroplasts.Strategies for efficiently engineering the small subunit of higher plant Rubisco are being developed |
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Supercharging CO2-fixation by plantsProjects are availble aimed at discovering fundamental issues relating to Rubisco biogenesis, its manipulation in chloroplasts and influence of photosynthetic C-assimilation and plant growth. |
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Unravelling novel Rubisco structures in algae.Many of the algae forming symbiotic associations with coral reef organisms have unique forms of Rubisco which we know very little about |
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Dissecting Rubisco catalysis in C3 and C4 plantsWe hope to understand what structural features make the Rubisco from C4 plants faster and integrate this feature into the slower Rubisco in C3 plants |
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Scrutinizing the influence of temperature on Rubisco catalysis.Improving our appreciation of how Rubisco catalysis is affected by higher temperatures is paramount towards understanding how ecosystem producitivty will be affected by climate change |
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Student opportunites in the phenomic analysis of CO2 acquisition by cyanobacteria |
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Student opportunities in molecular analysis of CO2 acquisition by cyanobacteria |
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Physiological and molecular regulation of stomatal movement |
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Genes, diet and environmentTo understand how the outside world is linked to DNA |
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Sexual selection in the field cricket Teleogryllus commodusWe are exploring a range of question relating to male singing behaviour, female mate choice, sperm competition, immunocompetence and diet. |
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CO2 acquisition by cyanobacteria and plants, and impact of climate changeProjects deal with CO2 acquisition by cyanobacteria and plants, and impact of climate change, and engineering plants that use less water |
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Sexual Selection and the Evolution of Sex RolesI am open to students proposing studies - be they meta-analyses (I can teach you the techniques), empirical work (as long as we have lab space or there is a suitable field site) or theoretical studies. |
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Have bacteria hijacked plant developmental pathways?We are investigating how bacteria have evolved to alter induce new root organs by interfering with planthormones. |
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Combatting plant parasitic nematodesWe are investigating the use of RNA interference technology to prevent plants from being devastated by root knot nematodes. |
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Can plants intercept bacterial small-talk?We are investigating whether the detection of bacterial quorum sensing signals by plants helps them combatting bacterial infection. |
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Co-evolution between Australian cuckoos and their hostsAn investigation of the co-evolutionary arms races between Australian cuckoos and their hosts |
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The impact of climate change on inter-specific interactionsAn investigation of the phenological mismatch hypothesis for interactions between cuckoos, their hosts and their prey in south-eastern Australia |
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The evolution of song in female birdsFemale birdsong is unusual in the northern hemisphere, so why do females of so many Australian species sing? |
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Distinguishing among patterns of extinction and speciation through geological and climatic changeThis study will develop a new view of how the diversity of life has evolved across vast periods of time by using and improving new statistical molecular modelling tools. |
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Effects of photobiomodulation on retinal traumaTreatment with NIR light following retinal trauma. |
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Fiddler Crabs: sex, territoriality and beyondI conduct research on a wide range of questions related to the mating and social behaviour of fiddler crabs. |
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Fiddler crabs: Current ProjectsMy students and I are currently conducting research on a wide range of topics related to the behaviour of fiddler crabs |
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Protective effect of photobiomodulation on the degenerative retinaNIR light treatment will be used to protect degenerative retinae from damage caused by excessive light |
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Student research projects in tumour immunology and liposome targeting |
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Student opportunites in molecular plant-microbe interactions |
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Genotypic variation in Rubisco between diverse wheatsRubisco varies between wheat species and we are seeking to relate different forms of Rubisco to photosynthetic performance in the leaf |
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Photosynthesis, food security and global change |
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The sensing and signalling of mechanical stress by roots- Genetic regulation of root:shoot communication and function under droughtRoots as environmental sensors and signalling agents to aerial meristems, expanding leaves and stomata. |
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Phytophthora pathogenicityPhytophthora species are fungus-like plant pathogens that cause destructive diseases in important crop plants worldwide |
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Infection of plants by rust fungiFungal pathogens secrete effector proteins that are transported into the cytoplasm of host plant cells |
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Transpiration efficiency genes. Manipulating the coordination of CO2 fixation and water loss in leaves- |
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The role of phospholipids and lipid signalling in the plasticity of growth and development |
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Coordination of cellular growth and proliferation. Development, patterns and morphogenesis. |
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Inhibiting innate immunity to prevent retinal degenerationThe innate immune response, specifically the complement system plays and important role in the progression of retinal degenerations, including AMD. In this project we trial a novel complement inhibitor in models of retinal degeneration |
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Dietary supplements in the prevention of retinal degenerationDietary supplements, especially natural products recently have become more prominent in biological research and their use in therapies is becoming more common. We are investigating their role in retinal degenerations. |
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Protective effect of photobiomodulation on light-induced retinal degenerationUsing NIR light to prevent or repair damage caused by bright light in the retina. |
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Phytophthora zoospore motilityMotile spores facilitate plant infection |
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Phytophthora zoospore adhesionRapid secretion of adhesives attaches pathogen spores to the surface of potential hosts |
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Phytophthora cell wall degrading enzymesSecretion of cell wall degrading enzymes are responsible for plant penetration |
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New Molecular Targets for Drugs to Treat Human and Animal Nematode ParasitesFunctional genomics of C. elegans to identify and validate new antinematode drug targets. |
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Fungal effector uptake into plant cellsPathogens secrete effector proteins that are transported into the cytoplasm of infected plant cells |
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New Control Methods for Plant-parasitic NematodesInvestigating the use of RNA interference to control plant-parasitic nematodes. |
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Olfactory Pattern Recognition in NematodesAn investigation of olfactory receptors in C. elegans |
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Olfactory receptors in C. elegansIdentifying potential olfactory receptors in C. elegans. |
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Shigella virulence and vaccine development |
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Functional genomics of serotype-converting bacteriophages of Shigella flexneri |
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Student research projects in plant development, root:shoot communication and drought signalling |
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Australian Alpine Seed and Seedling EcologyThis ARC linkage project examines the seed and seedling ecology of Alpine plants with an aim to conseration and management under climate change |
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The evolution and functional sigificance of leaf shapeThis project asks why leaf shapes vary and how do diverse leaf shapes evolve. |
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Evolution of the Y chromosomeCharacterising the marsupial Y |
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Monotreme dosage compensationEpigenetic regulation of the platypus X chromosomes |
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Marsupial X chromosome inactivationDiscovering the epigenetic signature associated with the inactive X in marsupials |
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Investigating immunomodulatory treatments for severe influenzaThis project looks at damping parts of the host immune response to influenza virus, so as to reduce morbidity and mortality. |
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Vitamin utilisation by malaria parasites |
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Investigating the interactions between respiration and photosynthesis in leaf photosynthetic function.Aim: Gain a greater understanding of the interactions between mitochondrial respiration and photosynthesis using targeted Arabidopsis respiration mutants. |
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Characterization of low and high CO2 sensitive Arabidopsis photosynthetic mutantsAim: To understand the function of previously unknown genes in the ability of photosynthesis to function under either low or high CO2 conditions. |
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Chromosomal evolution in the Social huntsman spider Delena cancerides.Understanding chromosomal evolution and its role in the speciation process |
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Evolution of the Australian OnychophoraMorphological, chromosomal and behavioural diversification in the Australian velvet worms ("Peripatus). |
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Pathways of photosynthetic electron flow under environmental stressWe track the light-induced electron transfers in situ in leaves working under defined environmental conditions. |
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Dynamic architecture of plant thylakoid membranes between light and darkThe architecture of photosynthetic membranes is not static, but undergoes re-organisation on illumination. Elucidation of the re-organisation helps us to understand the relation between the structure and function of the membranes. |
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Student projects in thylakoid function and structure |
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Photoprotection and photoinactivation of Photosystem IILight is both necessary for photosynthesis and harmful to the photosynthetic apparatus. This project investigates the photoprotection and photoinactivation of Photosystem II, and recovery from photoinactivation |
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Entropy as a novel determinant of photosynthetic structure and functionIn this project, we explore the photosynthetic apparatus as a system where light energy interacts with living matter, subject to thermodynamic constraints of which entropy has been seldom studied. |
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Above and below-ground specialization in Australian orchidsThis project is exploring the consequences of pollinator and fungal interactions for orchid speciation and vulnerability |
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The chemical, biochemical, genetic and ecological basis of pollinator-driven speciation in Australian orchidsThis project explores the critical role of pollinators in plant evolution and speciation |
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Limiting factors and impacts of climate change for endangered Australian orchidsThis project is assessing the role of multiple factors limiting endangered orchids |
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Honeybee visual systems |
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Control of Meristem Differentiation and Plant Architecture in LegumesPlant Development is Controlled by New Regulatory Molecules |
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Pigment Binding ProteinsDesigning proteins for binding Pigment-Chromophores |
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Molecular BiofuelsHigh Density Energy Storage |
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Tree water use, bushfires, and the implications for urban and rural water supplies |
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Theory and application of Maximum Entropy ProductionLooking at what plants and ecosystems do from a thermodynamic perspective |
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Photosynthetic Water SplittingHow Atmospheric Oxygen is Made |
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Plant optimisation modellingOptimisation models: new tools for global change science |
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Oxygen and Water Channels in ProteinsMaximizing Chemical Reactions |
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Artificial PhotosynthesisEngineering Model Photoactive Proteins |
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pH regulation in the malaria parasite |
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Herpes Simplex Virus and survival of infected cellsInvestigating herpes simplex virus (HSV) latency and the role of the immune system in survival of infected cells |
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Physics of pan evaporation |
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Understanding chloroplast/nuclear signaling and response pathways which determine photosynthetic capacityAim: To gain new insights into chloroplast/nuclear signaling pathways using in mutants where normal protein expression is perturbed by RNAi down regulation. |
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Understanding the cellular and genetic basis of differences in photosynthetic leaf capacity between Arabidopsis and a close mustard relative Hirschfeldia incana.Aim: To use comparative analysis of Arabidopsis and a closely related mustard species, Hirchfeldia incana, to gain an understanding of what determines various aspects of leaf photosynthetic capacity and its environmental plasticity. |
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Where physics and maths meet biologyResearch challenges at the physics-maths-biology interface |
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Coping with temperature extremes: morphological constraints on leaf function in a warmer, drier climate:We are combining field and laboratory studies to determine how hydraulic traits of evergreen leaves affect their tolerance of temperature extremes with change in atmospheric CO2 concentrations. |
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Entropy, information theory and biodiversityNew entropy-based tools for understanding ecological and genetic diversity |
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Immunological protection of marsupial pouch youngImmune tissues in marsupials develop after birth, raising questions about how they survive in a potentially hostile environment. |
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Salinity tolerance along an aridity gradient: linking physiological processes with morphological constraints on leaf function in mangrovesWe are studying interrelationships between salinity tolerance and the functional coordination of plant hydraulics, leaf morphology and gas exchange characteristics in mangroves. |
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Novel Small Molecule Regulators of Animal DevelopmentIdentification and characterisation of small plant-bioactive molecules that regulate mammalian development |
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Climate change and carbon gain in Antarctic mossesWe are studying interspecific differences in thermal tolerance of Antarctic mosses in relation to climate warming. |
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Ecophysiology of salinity and temperature tolerance in a changing world |
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Chromosome condensation and T cell development |
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Investigations into a possible therapeutic cancer vaccine. |
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Identification of novel splice variants in the human and mouse genomes |
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Structure and function of sulphate transportersThis project will involve investigation of function and interactions of sulphate transporters using mutagenesis, functional assays and yeast two hybrid approaches. |
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Chloroplast developmentThe plant organelles responsible for the plants ability to perform photosynthesis, the chloroplasts, are essential for plant growth and vitality. |
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Protein modification in chloroplastA light sensitive mutant, snowy cotyledon 4, has been isolated with a mutation in a CAAX-proteinase function |
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SCO Protein interaction partnersSeveral novel proteins have been identified in the mutant analysis of snowy cotyledon mutants, but mostly nothing is known about their function |
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Gain of function mutantsIn aim to unravel the regulatory network of chloroplast biogenesis second site mutants of snowy cotyledon 2 and snowy cotyledon 3 have been identified |
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Student research opportunities in immunologyProjects investigating T-cell development, cancer vaccines and novel splice variants available in the Fahrer lab. |
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Chlamydomonas as a model system to optimise lipid production for biofuelsOptimising microalgae for biofuel production |
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Understanding the role of key regulators in determining root architectureInvestigating the role of genes that control root architecture |
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Pigeon Foveal DevelopmentDetermine how the foveal location is specified during eye development |
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OCT analysis of earlier changes in the central retina of AMD and glaucomatous maculaeDetermine the normal and diseased parameters affecting visual acuity |
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Retinal function of the aged fovea using pigeon as a modelDetermine whether the function and cellular composition of the fovea changes with age |
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non-coding RNA and micro RNA genes in plantsIdentification and characterisation of non-coding RNA genes using a computational approach |
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Analysis of gene expressionDevelopments of new methods for functional interpretation of gene epression data |
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Organism specific sequence motifsDevelopment of a method of finding signiture sequences for for a phylogenetic group of organism |
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Evolutionary biology of Australian reptiles and amphibiansEvolutionary biology of Australian reptiles and amphibians |
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The Behavioural Ecology of MosquitofishWe are interested in a range of question related to behavioural decisions and life history evolution in Gambusia. |
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Drug resistance in the human malaria parasite |
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Design and evaluation of novel antimalarial drugs |
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Phototransduction and adaptation - the conversion of light into a neural signalOur primary research interest is to elucidate the molecular mechanisms underlying phototransduction and adaptation - the conversion of light into a neural signal, and subsequent recovery, in retinal rod and cone photoreceptors and in bipolar cells. |
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Characterisation of the microflora of Australian aeolian dust and its sources |
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Microbiological Aspects of Crohn's Disease |
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Microbial ecology of Lactobacillus strains in the chicken GIT: identification of persistent strains for use as live vectors |
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Characterisation of the chicken gut microflora |
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Identification and characterisation of membrane transport proteins |
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Photoprotective functions of xanthophyll pigments in avocado |
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Gene expression in the human maculaThe central region of the retina is vulnerable to degeneration, especially associated with aging. In this study we hope to identify genes which predispose humans to macular degeneration. |
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The Role of the immune system in photoreceptor degenerationThis project aims to identify the role that the immune system plays in the progression of retinal degeneration |
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The effect of 670nm light irradiation on growth and developmentRecent studies have shown that irradiation with 670nm light modulates expression of genes that regulate metabolism. In this study we aim to determine the effects of irradiation on new born rodents |
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The effect of 670nm light irradiation on growth and developmentThe aims of the project is to determine the effect of irradiation with 670nm light on growth and development of major organs |
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Development Aging and Degeneration of the RetinaWorldwide, loss of central vision is the major cause of impairment, untreatable blindness and poor quality of life. Projects in this lab are aimed at understanding aspects of development and aging that predispose the retina to degeneration. |
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Issues raised by reproductive genetic technologiesReproductive genetic technologies in Australia: regulation, communication and issues |
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Impact of new technologies on humans and societyProject topics can be designed in collaboration with students. Please email me to make an appointment to discuss possible projects |
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Ethics in science educationProject topics can be designed in collaboration with students. Please email me to make an appointment to discuss possible projects |
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Sensory processing in the spinal cordSensory information reaches the brain regions via direct (purely conductive) or indirect (neuronal processing) spinal cord pathways. This project will measure the contribution of these different routes by which the spinal cord relays sensory information. |
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Light therapy for neural regenerationThis project investigates the use of lasers for promoting regeneration after central and peripheral neural injury. |
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Adult stem cells for central nervous system repairBone marrow cells can cross the blood brain barrier in response to central nervous system (CNS) injury. |
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The bionic handThis project will use computational methods to decode signals generated from the central nervous system to control a bionic hand. |
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Cancer metabolismCancer cells use amino acid to generate energy. We are investigating amino acid transport and metabolism in cancer cells. |
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Behavioral properties of the visual brainWe have shown that the visual system is an active structure in which the animal's actions and intentions alter the way that visual information is processed. |
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Cortical development |
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Visual prosthesesThe so-called bionic eye is a device in which an array of stimulating electrodes is placed on the retina of a blind patient. |
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Reading the isotopic archive: carbon and oxygen stable isotope ratios as recorders of plant physiological processes |
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Honours and PhD student research in plant ecology and ecophysiologyResearch opportunities in the lab can be tailored to the interests of PhD, Honours and Undergrad students in a wide range of topics, including each of the current projects above. Contact Adrienne (Adrienne.Nicotra@anu.edu.au) for more information. |
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Phenotypic plasticity in plants: evolution, adaptation and its relevance in a changing climateThis research into plant responses to the novel environments posed by climate change will assess whether we can breed for more responsive crops or predict native plant tolerance of climate change. |
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Population variation for seed and seedling traits along a gradient: assessing plant species persistence in South West Western Australia under a changing climate.Examining the influence of projected climate change on seed and seedling traits in four seeder Banksia species in the South West Western Australia |
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Biological requirement for miRNA regulationTo understand the conceptual requirement for miRNA regulation |
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Elucidating the role of phenotypic plasticity and local adaptation in the evolution of Australian Pelargonium speciesIn this project we aim to assess phenotypic plasticity and local adaptation in water use traits of Australian Pelargonium species |
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Ecophysiology of alpine dioecious species: Examining sexual dimorphisms under harsh conditionsThis project is focused on ecophysiological differences between female and male plants that live at different altitudes in the alpine area of Mt. Kosciuszko, NSW. |
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Responding to change: phenotypic plasticity and local adaptation, case studies using native and invasive Erodium sppThis project investigates phenotypic plasticity of an invasive and native Erodium to water availability using field collected seeds in a series of greenhouse experiments |
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Ecology and evolution of Meconopsis Vig. (Papaveraceae) in Eastern TibetThis project examines ecological factors underlying the distribution of various Meconopsis species in Eastern Tibet, their phylogeny and the evolution of their breeding systems |
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The physiological and growth response of subtropical Eucalypts to defoliationThis project examines the response of sub-tropical Eucalypt species to repeated defoliation and water stress |
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Hormosira banksii in high intertidal rockpools on Kainga Reef, Burrawarra Point, NSWThis project examines seasonal variation in growth of algal species along the NSW coast. |
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Hormosira banksii in high intertidal rockpools on Kainga Reef, Burrawarra Point, NSWThis project examines seasonal variation in growth in rocky tidal algae on the NSW coast. |
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Hormosira banksii in high intertidal rockpools on Kainga Reef, Burrawarra Point, NSWThis project examines seasonal variation in growth of rocky tidal algae on the NSW coast |
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Dormancy and germination in Aciphylla glacialis, an alpine perennialThis project looks at whether seed dormancy in Aciphylla glacialis differs for seeds sourced from high and low altitudes in Kosciuszko National Park |
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The use of nanofibres for nervous repairThis project will use nanofibres as a grafting material for treatment of spinal cord and peripheral nerve injury |
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Understanding the mechanisms of thermal acclimation in the symbiotic algae (Symbiodinium) within cnidarian coralsIdentify gene(s) associated with thermal acclimation mechanisms in symbiotic algae (Symbiodinium) |
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Characterising the Mycosphaerella graminicola-wheat interactionA primary biosecurity threat to the Australian wheat industry |
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Summer scholarships in plant ecology and ecophysiologyThis summer projects in the lab will include alpine ecology and reproductive biology as well as glasshouse projects on phenotypic plasticity in response to water availability. Contact Adrienne (Adrienne.Nicotra@anu.edu.au) for more information. |
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Student research in stable isotopes and ecophysiologyEnvironmental plant biology |
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Characterization of low CO2 sensitive Arabidopsis photosynthetic mutants: To understand the function of previously unknown genes in the ability of photosynthesis to function under low CO2 conditions. |
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Evolution of Vertebrate Sex Chromosomes and Dosage CompensationEnquiries from prospective students are welcome |
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Synthetic nanotubes to mimic biological ion channelsSynthetic nanotubes to mimic biological ion channels |
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Membrane transport proteins of the malaria parasite and their roles in mediating drug resistanceEnquiries from prospective students are welcome. |
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Marsupial genomicsEnquiries from prospective students are welcome for any of the above projects. |
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The role of phospholipid flippases in the immune systemB-cell development requires a specific distribution of membrane phospholipids. Mutations in enzymes mediating phospholipid transport can cause immunodeficiency. |
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Rust resistance in Australian MyrtaceaeThe exotic plant pathogen myrtle rust has recently arrived in Australia with devastating effects for the environment and dependent industries. |
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X inactivation in human placentaeIn humans, the fetus employees sex specific growth strategies to cope with a stress (e.g.asthma) during pregnancy. Are these sex-specific differences related to differences in expression of genes on the X chromosome? |
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Escherichia albertii: an avian and human pathogen |
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Comparison of Escherichia coli in birds and humans |
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E. coli within and among host dynamics in poultry |
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Distribution of novel Escherichia species |
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Role of gonadotrophins in the maintenance of reproductive quiescence of the female tammar wallaby.Study aimed at understanding role of GnRH in maintenance of corpus luteum and/or blastocyst quiescence in tammar wallabies |
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Effect of endocrine disruptors on reproduction in daphniidsEndocrine disruptors are chemicals produced by humans that can affect a number of hormonally controlled processes in other organisms. This study will examine how reproduction is affected by endocrine disruptors in the aquatic daphniids (Crustacea) |
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Effects of hyperoxia and 670nm light on brain development in mice.This project will examine the effects of 670nm light treatment on different regions of the brain. |
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Effects 670nm light on oxygen-induced retinopathy in miceThis project aims to investigate a new treatment for retinopathy of prematurity |
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Effect of 670 nm light on lung developmentNewborn mice treated with red light grow faster than littermates, and their lungs weigh more. This project will examine lung development in treated mice and littermates |
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Localization, and effects of inhibition, of macrophage chemoattractant molecules in the light-induced model of retinal degeneration.Retinal degeneration is mediated by macrophages attracted into the retina by chemoattractant signals. How does modification of the chemoattractant signal effect progression of degeneration? |
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Immune genes of the bearded dragonCharacterisation of the reptilian immune system is required to gain a greater understanding of the evolutionary history of the vertebrate immune system |
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Avoiding coral bleachingInvestigation into the repair of damaged photosynthetic machinery in symbiotic algae (Symbiodinium) within corals |
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Finding the oldest molecular fossils of cyanobacteria1.64 billion years ago Cyanobacteria layed down Biomarkers into sediments |
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Mycotoxin discovery and characterisationWhat mycotoxins compounds do necrotrophic fungal pathogens of wheat produce and what is their role? |
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New approaches to discovering biodiversity and understanding its response to climate changeNew technologies will be used to predict and discover biodiversity hotspots in Australia, especially in the, as yet, poorly-known monsoonal tropics. |
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Landscape GenomicsPopulation based genome sequencing across environmental samples |
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Genome Wide Association MappingDetermine the Genetic Architecture of Adaptive Traits in Plants |
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Understanding novel epigenetic mechanisms using a model plant.A research project suitable for an undergraduate research project or ASC. |
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How does your garden grow? Scaling functional traits to whole-plant growth |
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Will stomatal responses to humidity and carbon dioxide constrain tropical forest productivity as atmospheric carbon dioxide rises? |
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Why does cancer chemotherapy fail?Overcoming drug efflux pumps to restore sensitivity to anti-cancer drugs |
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Lipid flipping in vision: seeing is believing!Does aberrant phospholipid flip-flop underpin visual disorders? |
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Starving tumoursPerturbation of metabolic changes in solid tumours to effect therapy |
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Bioinformatic methods for epigenomic data analysisThe project involves the development of new methods to understand epigenetic regulatory mechanisms. |
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Coral development and comparative genomicsData from the transcriptomes and genomes of various corals are used to gain insight into genes and regulatory networks that underpin the development and physiology of corals. |
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Erythrocyte membrane modifications during malaria infection |
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Function of molecular chaperones in the export and display of parasite proteins |
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Cellular adaptations that allow the transmission and survival of Plasmodium falciparum when taken up by the mosquito |
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Molecular tools to reveal protein function and identify drug targets |
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Apicoplast and mitochondrial metabolism in apicomplexan parasitesWhat are the metabolic functions of the apicoplast and mitochondrion in apicomplexan parasites? |
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Apicoplast and mitochondrial biogenesis in apicomplexan parasitesHow are the apicoplast and mitochondrion of apicomplexan parasites made? |
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The unique cell biology of Toxoplasma gondiiWhat makes Toxo tick? |
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Cell biology and metabolism of apicomplexan parasitesEnquiries from prospective students and researchers with an interest in cell biology, biochemistry, parastiology and/or evolution welcome! |
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New antibiotics that target membrane channelsDesigning peptides that interfere with bacterial ion channels to combat antibiotic resistance |
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How do biological molecules distinguish between ions?Although critical in biology, telling potassium from sodium is harder than you think! |
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Biologically inspired membranes for the efficient desalination of waterReducing the cost of seawater desalination by copying the action of cell membranes |
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Watching proteins as they change shapeMonitoring the conformational changes of proteins |
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Processes of community assemblyDeveloping bioinformatic tools for understanding the dynamics of : speciation, colonization, extinction and invasion within species assemblages |
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Origins of a biodiversity hotspot floraA phylogenetic analysis of the diversification of the Australian Proteaceae |
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EvolvabilityExploring the causes, consequences and practical applications of evolvability |
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Climate change and leaf eating mammalsMany wild herbivores show seasonal preferences for different plants or plant parts. |
